Sodium butyrate activates the extrinsic and intrinsic apoptotic processes in murine cementoblasts.

Background: : The metabolic by-product butyric acid of Gram-negative anaerobic bacteria can invoke pathological effects on periodontal cells resulting in inflammation and further destruction of periodontium. However, limited researches on the effects of butyric acid on cementoblasts were reported. Therefore, this study aimed to investigate the type of cell death in murine cementoblast (OCCM.

When synthetic biology meets medicine.

In recent years, the world has faced significant challenges with the coronavirus disease 2019 (COVID-19) pandemic, as well as other infectious diseases such as Zika and Ebola. Furthermore, the rapid rise of non-communicable diseases such as diabetes, heart disease, and cancer has placed tremendous strain on healthcare resources and systems. Unfortunately, advancements in drug development, diagnostics, and therapeutics have struggled to keep pace with the emergence and progression of diseases, necessitating the exploration of new technologies for the discovery and development of biomedicines and biotherapies.

Deep learning-enabled exploration of global spectral features for photosynthetic capacity estimation.

Spectral analysis is a widely used method for monitoring photosynthetic capacity. However, vegetation indices-based linear regression exhibits insufficient utilization of spectral information, while full spectra-based traditional machine learning has limited representational capacity (partial least squares regression) or uninterpretable (convolution). In this study, we proposed a deep learning model with enhanced interpretability based on attention and vegetation indices calculation for global spectral feature mining to accurately estimate photosynthetic capacity.

A pan-cancer analysis: predictive role of ZNF32 in cancer prognosis and immunotherapy response.

The zinc finger protein 32 (ZNF32) has been associated with high expression in various cancers, underscoring its significant function in both cancer biology and immune response. To further elucidate the biological role of ZNF32 and identify potential immunotherapy targets in cancer, we conducted an in-depth analysis of ZNF32. We comprehensively investigated the expression of ZNF32 across tumors using diverse databases, including TCGA, CCLE, TIMER2.

Unraveling the functional complexity of the locus coeruleus-norepinephrine system: insights from molecular anatomy to neurodynamic modeling.

The locus coeruleus (LC), as the primary source of norepinephrine (NE) in the brain, is central to modulating cognitive and behavioral processes. This review synthesizes recent findings to provide a comprehensive understanding of the LC-NE system, highlighting its molecular diversity, neurophysiological properties, and role in various brain functions. We discuss the heterogeneity of LC neurons, their differential responses to sensory stimuli, and the impact of NE on cognitive processes such as attention and memory.