Publications by authors named "C M Simeoni"
Article Synopsis
- The study explores the resurgence of Oropouche fever in Brazil from 2023 to 2024, focusing on virological factors influencing the outbreak after decades of sporadic cases.
- Researchers gathered data from various sources, analyzed serum samples from patients and previously infected individuals, and performed molecular tests to understand the virus's characteristics and behavior.
- The findings showed an extraordinary spike in cases in 2024, with over 8,600 confirmed incidents, highlighting the virus's widespread distribution across all regions of Brazil.
Article Synopsis
- * The study included data from 2015 to 2024, revealing a dramatic rise in infections—83.2% occurring in the North—and identified a novel OROV strain that is much more virulent than the original prototype.
- * The new OROV strain was shown to replicate significantly faster and more effectively in mammalian cells, with a notable decrease in neutralizing antibodies from individuals previously infected, indicating a potential threat to public health.
SARS-CoV-2 can induce vascular dysfunction and thrombotic events in patients with severe COVID-19; however, the cellular and molecular mechanisms behind these effects remain largely unknown. In this study, we used a combination of experimental and in silico approaches to investigate the role of PC in vascular and thrombotic events in COVID-19. Single-cell RNA-sequencing data from patients with COVID-19 and healthy subjects were obtained from the publicly available Gene Expression Omnibus (GEO) repository.
View Article and Find Full Text PDFThe COVID-19 pandemic caused by the SARS-CoV-2 virus has highlighted the need for serological assays that can accurately evaluate the neutralizing efficiency of antibodies produced during infection or induced by vaccines. However, conventional assays often require the manipulation of live viruses on a level-three biosafety (BSL3) facility, which presents practical and safety challenges. Here, we present a novel, alternative assay that measures neutralizing antibodies (NAbs) against SARS-CoV-2 in plasma using flow cytometry.
View Article and Find Full Text PDFMonkeypox virus (MPXV) infection was classified as a public health emergency of international concern by the World Health Organization (WHO) in 2022, being transmitted between humans by large respiratory droplets, in contact with skin lesions, fomites, and sexually. Currently, there are no available accessible and simple-to-use diagnostic tests that accurately detect MPXV antigens for decentralized and frequent testing. Here, we report an electrochemical biosensor to detect MPXV antigens in saliva and plasma samples within 15 min using accessible materials.
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