A retrospective cohort analysis of alignment parameters for spinal tumor patients with instrumentation at the cervicothoracic junction.

Background: Previous research on spinal alignment and postoperative outcomes after cervical and upper thoracic fixation has suggested that clinical and patient-reported outcomes are improved when certain anatomical parameters are maintained. These parameters include the cervical sagittal vertical axis (cSVA), C2 and T1 slopes, and cervical lordosis (CL). For patients with primary and metastatic tumors involving the subaxial cervical and/or upper thoracic spine, there is minimal guidance on how to apply these parameters.

Combinatorial therapies for epigenetic, immunotherapeutic, and genetic targeting of chordoma.

Purpose: Chordoma, a rare malignancy of the axial skeleton and skull base, presents significant therapeutic challenges due to the high rates of tumor recurrence and resistance. While surgical resection and radiation therapy remain the gold standard of treatment, the lack of additional treatment options necessitates the exploration of novel therapies. Combinatorial therapies hold significant potential in shaping patient prognosis.

Tumor sequencing before and after neoadjuvant chemoradiotherapy in locally advanced rectal cancer: Genetic tumor characterization and clinical outcome.

Background And Purpose: Neoadjuvant chemoradiotherapy (NCRT) is a standard treatment option for locally advanced rectal cancer. However, there is still conflicting data about the genetic landscape and potential dynamics during and after NCRT. This study evaluated oncogenic driver mutations before NCRT and investigated corresponding resection samples after treatment.

Real-time monitoring as a tool for comparison of electrochemical advanced oxidation processes for the decolourisation of azo and indigoid dyes.

The widespread use of synthetic dyes has led to the release of substantial amounts of dye-contaminated wastewater, posing significant environmental and health concerns. This study focuses on the use of anodic and electrochemically activated persulfate oxidation for the degradation of organic contaminants. Specifically, the structural variations of nine dyes in the indigoid and azo families, and their impact on the efficiency of electrochemical oxidation were analysed.