Publications by authors named "C M Scally"
Background: The Peritoneal Cancer Index (PCI), calculated intraoperatively, has previously yielded mixed results when correlated with computed tomography. This study aimed to quantify variation in this scoring method comparing radiologists' and surgeons' radiologic PCI (rPCI) assessment.
Methods: The rPCI of 104 patients treated at a single institution for peritoneal carcinomatosis was calculated by an abdominal radiologist and a surgeon.
Article Synopsis
- Malignant peripheral nerve sheath tumors (MPNSTs) show altered DNA methylation patterns, suggesting these changes could be used as specific biomarkers for NF1 patient screening.
- Researchers conducted a study involving DNA methylation profiling from tumor and adjacent tissue samples of 13 MPNST patients, finding 73 candidate CpGs that could distinguish MPNSTs from neurofibromas.
- Five validated biomarkers demonstrated high sensitivity and specificity in tissue detection, and higher methylation levels were observed in plasma tests, indicating potential for early detection of MPNST in NF1 patients.
Background: The course of subclinical gastrointestinal stromal tumors (GISTs) is variable. The management of small GISTs is not well-defined.
Methods: Records of patients presenting with small GISTs with documented follow-up appointment at our institution between 2016 and 2022 were identified and reviewed.