Publications by authors named "C M Reever"
SCN8A developmental and epileptic encephalopathy (DEE) is a severe epilepsy syndrome resulting from mutations in the voltage-gated sodium channel Nav1.6, encoded by the gene SCN8A. Nav1.
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- The study assessed how bactibilia (bacteria in bile) relates to post-surgery infections in patients with obstructive jaundice by analyzing bile cultures during surgery.
- Researchers examined 76 patients and found that 33% of those who had a preoperative endoscopic retrograde cholangiopancreatography (ERCP) tested positive for bactibilia compared to only 4% without it.
- Postoperative infections were significantly more common in patients with bactibilia (38%) than in those without (7%), indicating that positive bile cultures increase infection risk after surgery.
By comparison to the other subtypes of muscarinic receptors, very little is known about the binding properties, locations, mechanisms and physiological functions of the M5 (m5)* receptor subtype. Studies of the m5 receptor have been hampered by the lack of m5-selective ligands or antibodies and a source that endogenously expresses predominantly the m5 receptor subtype. We have developed a pharmacological labeling strategy using the non-selective muscarinic antagonist [3H]NMS, in the presence of muscarinic antagonists and toxins in green mamba venom to occlude the m1-m4 receptor subtypes, to selectively label the m5 receptor subtype.
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