Publications by authors named "C M R Remedios"
Article Synopsis
- Pregnancy causes significant changes in a woman’s heart and vascular system, but some women can develop a heart condition called peripartum cardiomyopathy (PPCM) during or after pregnancy which can lead to heart failure.
- A study used mass spectrometry to compare protein and metabolite profiles from heart tissue of patients with end-stage PPCM against those with dilated cardiomyopathy (DCM) and non-failing heart donors, aiming to understand the molecular differences.
- Findings revealed two specific proteins (SBSPON and TNS3) were downregulated in PPCM, disrupting tissue remodeling, while certain metabolites showed abnormal levels indicating altered metabolic functions; both PPCM and DCM shared some inflammatory pathways but differed significantly in thyroid
The second-generation myosin activator danicamtiv (DN) has shown improved function compared with the first-generation myosin activator omecamtiv mecarbil (OM) in nonfailing myocardium by enhancing cardiac force generation but attenuating slowed relaxation. However, whether the functional improvement with DN compared with OM persists in remodeled failing myocardium remains unknown. Therefore, this study aimed to investigate the differential contractile responses to myosin activators in nonfailing and failing myocardium.
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- * The study analyzed tissues from 97 patients with symptomatic obstructive HCM through RNA-sequencing and mass spectrometry, revealing significant differences in gene and protein expressions between males and females, though overall profiles were similar.
- * Findings indicate that HCM females show greater downregulation of hypertrophy pathways and have more differentially expressed proteins compared to control females than what is observed in males, highlighting biologically relevant sex-specific differences in disease mechanisms.
Indomethacin (INDO) has a mechanism of action based on inhibiting fatty acids cyclooxygenase activity within the inflammation process. The action mechanism could be correlated with possible anticancer activity, but its high toxicity in normal tissues has made therapy difficult. By the coprecipitation method, the drug carried in a layered double hydroxides (LDH) hybrid matrix would reduce its undesired effects by promoting chemotherapeutic redirection.
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- Hypertrophic cardiomyopathy (HCM) is a heart condition caused by gene mutations in about half of the patients, while the other half don't have these mutations.
- Researchers studied heart tissue from patients to understand how energy use and fat processing changes in both groups of HCM patients.
- They found different metabolic changes between the two groups that affect how the disease progresses in the heart.