Publications by authors named "C M Preece"
To enable robust expression of transgenes in stem cells, recombinase-mediated cassette exchange at safe harbor loci is frequently adopted. The choice of recombinase enzyme is a critical parameter to ensure maximum efficiency and accuracy of the integration event. We have explored the serine recombinase family of site-specific integrases and have directly compared the efficiency of PhiC31, W-beta, and Bxb1 integrase for targeted transgene integration at the Gt(ROSA)26Sor locus in mouse embryonic stem cells.
View Article and Find Full Text PDFThe Controls Over Mesopelagic Interior Carbon Storage (COMICS) cruise DY086 took place aboard the RRS Discovery in the South Atlantic during November and December, 2017. Physical, chemical, biogeochemical and biological data were collected during three visits to ocean observatory station P3, off the coast of South Georgia, during an austral spring bloom. A diverse range of equipment including CTD-rosette, Acoustic Doppler Current Profiler (ADCP), net deployments, marine snow catchers (MSCs), Stand Alone Pump System (SAPS) and PELAGRA Sediment Traps were used to produce a comprehensive, high-quality dataset.
View Article and Find Full Text PDFArticle Synopsis
- The study addresses treatment disparities for kidney failure between First Nations people (Aboriginal and Torres Strait Islander) and non-First Nations individuals in Australia, aiming to improve home-based treatment options.
- It involves a multicenter approach to collect data from health services, staff, and patients to understand the factors affecting health outcomes and service utilization.
- The research, funded by the National Health and Medical Research Council of Australia, has received multiple ethics approvals to ensure it meets ethical standards.
Purpose: The factors affecting women's willingness to participate (WTP) in breast cancer (BC) prevention trials are poorly understood. This study aimed to identify the characteristics of interventions associated with a higher WTP among high BC risk women.
Methods: Women who self-identified as being at an increased risk of BC were recruited to a cross-sectional study of WTP in BC prevention trials.
Article Synopsis
- Improving energy provision in failing hearts by increasing the creatine kinase (CK) system is a promising target for therapy, but high creatine levels can lead to heart issues.
- A study showed that double transgenic mice (dTg) with both elevated creatine transporter (CrT) and muscle CK (CKM) did not alleviate adverse heart conditions due to decreased CK activity.
- The research concluded that moderate creatine levels are safe, but excessive amounts are harmful, suggesting future work should focus on maintaining CK activity to maximize the benefits of both creatine and CK enhancement in heart treatment.