Publications by authors named "C M Parry"
Coronavirus disease 2019 (COVID-19), caused by infection with the enveloped RNA betacoronavirus, SARS-CoV-2, led to a global pandemic involving over 7 million deaths. Macrophage inflammatory responses impact COVID-19 severity; however, it is unclear whether macrophages are infected by SARS-CoV-2. We sought to identify mechanisms regulating macrophage expression of ACE2, the primary receptor for SARS-CoV-2, and to determine if macrophages are susceptible to productive infection.
View Article and Find Full Text PDFIntroduction: Rapid detection and identification of pathogens and antimicrobial susceptibility is essential for guiding appropriate antimicrobial therapy and reducing morbidity and mortality associated with sepsis.
Objectives: The metabolic response of clinical isolates of Klebsiella oxytoca exposed to different concentrations of ciprofloxacin (the second generation of quinolones antibiotics) were studied in order to investigate underlying mechanisms associated with antimicrobial resistance (AMR).
Methods: Metabolomics investigations were performed using Fourier-transform infrared (FT-IR) spectroscopy as a metabolic fingerprinting approach combined with gas chromatography-mass spectrometry (GC-MS) for metabolic profiling.
Article Synopsis
- Understanding the genetics of Parkinson's disease (PD) is crucial for developing effective treatments globally, but there's a lack of diversity in current research.
- The Black and African American Connections to Parkinson's Disease (BLAAC PD) study aims to investigate the genetics of PD specifically in Black and African American populations, addressing this gap.
- With a goal of enrolling up to 4,000 participants, including both individuals with PD and controls, the study emphasizes community involvement and aims to remove barriers to participation in research.
Positron emission tomography imaging using radiolabeled dolutegravir (DTG) is an interesting approach to understand the biodistribution of this antiretroviral drug at HIV-1 sanctuary sites. In the course of clinical translation, we depict herein an improved and pharmaceutically compliant radiosynthesis of [F]DTG from an original tin precursor. The radiosynthesis was achieved in two steps by copper-mediated radiofluorination, followed by enol ether deprotection using a kit-based AllInOne module.
View Article and Find Full Text PDFArticle Synopsis
- The COVID-19 pandemic significantly disrupted tuberculosis (TB) treatment, particularly impacting directly observed therapy (DOT) adherence programs in South Africa.
- Data from a study comparing DOT adherence rates before (pre-COVID-19) and after (post-COVID-19 lockdown) revealed marked increases in non-adherence rates, with the highest non-adherence observed immediately after the first lockdown.
- The findings suggest that the negative impact on DOT adherence persisted post-lockdown, highlighting the need for further investigation into the barriers that worsened treatment adherence during and after the pandemic.