Mechanical stress in a solid ellipsoid model of the lung after thoracoscopic surgery for spontaneous pneumothorax.

Background: Newly formed bullae after video-assisted thoracoscopic surgery (VATS) bullectomy in primary spontaneous pneumothorax (PSP) are an important etiology for recurrence and are associated with mechanical stress along the stapling line. However, the distribution or pattern of stress after VATS bullectomy has not been thoroughly investigated. Our aim was to analyze the stress distribution following lung resection.

Novel anti-CD73-IL-2v bispecific fusion protein augments antitumor immunity by alleviating immunosuppressive adenosine pathways in CD8 T cells.

Background: Adenosine accumulated in the tumor microenvironment functions as an immune-modulating factor, exerting immunosuppressive actions via adenosine A2A/A2B receptor (A2AR/A2BR) in various immune cell types. CD73, a key enzymatic regulator responsible for adenosine production, is frequently overexpressed in diverse cancers, and its overexpression is associated with reduced responsiveness to conventional anti-cancer drug treatments such as chemotherapy, radiation therapy, targeted therapy, or immunotherapy. Despite numerous therapeutic applications of IL-2 in cancer immunotherapy, the relationship between the CD73-adenosine axis and IL-2-based immunotherapy remains largely unexplored.

Trauma appraisals in the first month after sexual trauma differentially predict subsequent mental and physical health sequelae.

Objective: Sexual trauma is highly prevalent, particularly in women. Cognitions play a critical role in trauma recovery and may predict chronic mental and physical health difficulties. However, existing studies of cognitions following trauma have focused largely on global meanings (i.

Dual-MOF-Layered Films via Solution Shearing Approach: A Versatile Platform for Tunable Chemiresistive Sensors.

Metal-organic frameworks (MOFs) are ideal for gas sensing due to their high porosity and chemical diversity. However, their low electrical conductivity has traditionally limited their application in chemiresistive-type sensors. The recent development of electrically conductive MOFs (cMOFs) has addressed this limitation.

Comparing the Effects of Adequate and Insufficient Sleep on the Mental Health, Behavioral Outcomes, and Daily Lives of South Korean Adolescents.

Adequate sleep is critical for adolescents' physical and mental health. However, academic demands and lifestyle habits lead to insufficient sleep among many adolescents. This study examined the relationship between sleep patterns and general characteristics, health behaviors, and mental health among South Korean adolescents.