Publications by authors named "C M Niculae"
Article Synopsis
- A measles epidemic driven by D8 genotype strains has been ongoing in the country since 2022, with a significant increase in liver-related complications compared to the previous outbreak.
- A study analyzed clinical data from 228 hospitalized adult patients during the current outbreak and 130 from the previous one, revealing higher instances of liver involvement and hepatocellular injury in the recent cases.
- The findings suggest that newer MeV strains may have a stronger link to liver issues, highlighting the need for ongoing observation, despite low mortality rates associated with these liver complications.
Article Synopsis
- Knee osteoarthritis (KOA) is the most common type of osteoarthritis, diagnosed through clinical assessment and knee X-rays, and is influenced by various prognostic and risk factors like age, BMI, and physical activity.
- A study at the University Emergency Hospital in Bucharest included 70 KOA patients, examining those needing surgical vs. non-surgical treatments based on specific criteria, focusing on patients over 45 with knee pain and radiographic evidence of KOA.
- Results showed that patients requiring total knee arthroplasty (TKA) were significantly older than those needing other treatments, with a notable difference in age and a higher prevalence of KOA in women.
There is existing controversy regarding the efficacy of tigecycline (TG) in treating complicated urinary tract infections (cUTIs) because of its pharmacokinetic concerns. We present three patients with cUTIs caused by carbapenem-resistant gram-negative (GN) pathogens successfully treated with high-dose tigecycline (HDT)-based regimens, as cefiderocol and aztreonam were not available in our country. The first case describes a 67-year-old patient with diabetes, prostate cancer, and double J ureteral stenting who was hospitalized with a febrile, complicated urinary tract infection (cUTI).
View Article and Find Full Text PDF: Central nervous system (CNS) involvement is a complication of COVID-19, adding to disease burden. The aim of this study is to identify the risk factors independently associated with CNS involvement in a cohort of patients hospitalized with severe forms of COVID-19 and the risk factors associated with all causes of in-hospital mortality and assess the impact of CNS involvement on in-hospital mortality of the severe COVID-19 patients. : We performed a retrospective observational cohort study including adult patients with severe or critical forms of COVID-19 with and without new-onset CNS manifestations between March 2020 and December 2022.
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