Endogenous Endophthalmitis Caused by Prototheca Microalga in Birman Cat, Spain.

We identified Prototheca spp. microalga in ocular samples of a cat in Spain with nontreatable endogenous endophthalmitis. Within 2 years, the eye lesions progressively worsened and neurologic signs appeared, suggesting systemic spread of the infection.

Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii.

Monoclonal antibodies (mAbs) are a major class of biopharmaceuticals manufactured by well-established processes using Chinese Hamster Ovary (CHO) cells. Next-generation biomanufacturing using alternative hosts like Komagataella phaffii could improve the accessibility of these medicines, address broad societal goals for sustainability, and offer financial advantages for accelerated development of new products. Antibodies produced by K.

Presumed calcific band keratopathy in a 10-month-old domestic shorthair cat.

Objective: To describe a case of presumed band keratopathy in a young cat with no known history of corneal disease who was not receiving topical phosphate-based steroids.

Animal Studied: A 10-month-old domestic shorthair cat was evaluated for severe ocular discomfort that did not improve despite the initiation of topical antibiotic treatment.

Methods: A complete ophthalmic examination and ancillary tests such as biomicroscopy and corneal cytology were performed at the time of presentation.

The Complex Genetic Legacy of Hybridization and Introgression between the Rare van der Werff and the Widespread van der Werff (Lauraceae).

Hybridization and introgression are complex evolutionary mechanisms that can increase species diversity and lead to speciation, but may also lead to species extinction. In this study, we tested the presence and genetic consequences of hybridization between the rare and Ecuadorian endemic van der Werff and the widespread van der Werff (Lauraceae). Phenotypically, some trees are difficult to identify, and we expect that some might in fact be cryptic hybrids.

Exercise reduces physical alterations in a rat model of fetal alcohol spectrum disorders.

Background: Prenatal alcohol exposure (PAE) has serious physical consequences for children such as behavioral disabilities, growth disorders, neuromuscular problems, impaired motor coordination, and decreased muscle tone. However, it is not known whether loss of muscle strength occurs, and which interventions will effectively mitigate physical PAE impairments. We aimed to investigate whether physical alteration persists during adolescence and whether exercise is an effective intervention.