Publications by authors named "C M NOYES"
Continental glaciations during the Pleistocene Epoch created complex systems of aquifers and aquitards across many northern regions of the Earth. The low hydraulic conductivities of glacial till aquitards suggest that limited recharge will reach the underlying aquifers, potentially preserving old groundwaters. Here, we characterize the recharge history in intertill and buried valley aquifers in Saskatchewan, Canada using C, H, He δH, δO, and major ions.
View Article and Find Full Text PDFIntroduction: Language that assumes gender and sex are binary and aligned is pervasive in medicine and is often used when teaching on physiology and pathology. Information presented through this lens oversimplifies disease mechanisms and poorly addresses the health of gender and sexually diverse (GSD) individuals. We developed a training session to help faculty reference gender and sex in a manner that would be accurate and inclusive of GSD health.
View Article and Find Full Text PDFArticle Synopsis
- Human cancers, including small cell lung cancer (SCLC), often show re-expression of germline factors like DDX4, which is linked to enhanced cell motility and resistance to the chemotherapy drug cisplatin.
- DDX4 appears to upregulate proteins involved in DNA repair and immune/inflammatory responses, suggesting its role in promoting tumor growth and survival.
- Higher levels of DDX4 in SCLC patients are associated with poorer survival rates, indicating that DDX4 may help cancer cells survive by boosting pathways related to DNA damage response and immune evasion, especially during chemotherapy.
Rationale: Noble gases are widely used as physically based climate proxies, notably in dissolved water samples as tracers of past recharge temperature in groundwater and air-sea gas exchange processes in seawater. Recent advances in measuring large-volume samples of dissolved noble gas isotopic ratios at high precision have expanded the range of climate parameters that can be interpreted.
Methods: We build on prior methods for measuring noble gas stable isotopes at high precision with a new large-volume equilibration (LVE) method wherein sample gases are equilibrated in the sample flask between the dissolved phase and the headspace.