Publications by authors named "C M Motley"

Article Synopsis
  • * The study proposes a new evaluation method that analyzes patient interactions and behaviors using eye movement and speech data during tests like the Stroop Test, improving the depth of insights beyond traditional measures.
  • * Findings reveal distinct metrics for different NDs, enhancing diagnosis and correlating with clinical scales, suggesting this comprehensive approach could improve diagnostic accuracy and patient care in neurodegenerative disorders.
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The clinical observation and assessment of extra-ocular movements is common practice in assessing neurodegenerative disorders but remains observer-dependent. In the present study, we propose an algorithm that can automatically identify saccades, fixation, smooth pursuit, and blinks using a non-invasive eye tracker. Subsequently, response-to-stimuli-derived interpretable features were elicited that objectively and quantitatively assess patient behaviors.

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Neuroinflammation through enhanced innate immunity is thought play a role in the pathogenesis of Parkinson's disease (PD). Methods for monitoring neuroinflammation in living patients with PD are currently limited to positron emission tomography (PET) ligands that lack specificity in labeling immune cells in the nervous system. The colony stimulating factor 1 receptor (CSF1R) plays a crucial role in microglial function, an important cellular contributor to the nervous system's innate immune response.

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Article Synopsis
  • Motor impairments are just one aspect of Parkinson's disease (PD); cognitive and linguistic issues also play a significant role.
  • This study investigates speech-derived biomarkers, focusing on multilingual data to enhance early PD diagnosis and ongoing monitoring.
  • A total of 24 biomarkers were evaluated across multiple languages, revealing key acoustic and linguistic features that can reliably differentiate individuals with PD from healthy participants.
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Purpose Of Review: The presence of social support is a major determinant of positive health outcomes among people with cardiovascular disease (CVD); however, little is known about the most effective strategies for enhancing social support among this population. The aim of this scoping review was to describe the effectiveness of interventions seeking to enhance social support among people living with CVD and synthesize the evidence.

Recent Findings: A systematic search for articles that (a) reported on interventions which may enhance social support and (b) included a measure of social support revealed 21 studies.

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