Neurodevelopmental and behavioural disorders after perioperative invasive mechanical ventilation in paediatric surgical admissions.

Background: Children with a respiratory disease requiring invasive mechanical ventilation (IMV) in the paediatric intensive care unit (PICU) have an elevated risk for subsequent neurodevelopmental and behavioural disorders (NDBD). This study evaluates NDBD in children receiving IMV during surgical admissions.

Methods: Children enrolled in Texas Medicaid between 1999 and 2012 with a surgical admission were evaluated.

Computational Modeling Reveals a Catch-and-Guide Interaction Between Kinesin-1 and Tubulin C-Terminal Tails.

The delivery of intracellular cargoes by kinesins is modulated at scales ranging from the geometry of the microtubule networks down to interactions with individual tubulins and their code. The complexity of the tubulin code and the difficulty in directly observing motor-tubulin interactions have hindered progress in pinpointing the precise mechanisms by which kinesin's function is modulated. As one such example, past experiments show that cleaving tubulin C-terminal tails (CTTs) lowers kinesin-1's processivity and velocity on microtubules, but how these CTTs intertwine with kinesin's processive cycle remains unclear.

High intensity exercise programme in patients with hypertrophic cardiomyopathy: a randomized trial.

Background And Aims: The feasibility and impact of high intensity exercise programmes in patients with hypertrophic cardiomyopathy (HCM) are unknown. This study was conducted to determine the feasibility of a high intensity exercise programme and explore safety and efficacy outcomes in patients with HCM.

Methods: Participants were randomized to a 12-week supervised exercise programme (n = 40) in addition to usual care, or usual care alone (n = 40).

Hardware-efficient quantum error correction via concatenated bosonic qubits.

To solve problems of practical importance, quantum computers probably need to incorporate quantum error correction, in which a logical qubit is redundantly encoded in many noisy physical qubits. The large physical-qubit overhead associated with error correction motivates the search for more hardware-efficient approaches. Here, using a superconducting quantum circuit, we realize a logical qubit memory formed from the concatenation of encoded bosonic cat qubits with an outer repetition code of distance d = 5 (ref.

Supporting Families to 'Make the Most' of the Relationship Between Their Companion Dogs and Their Children with Autism Spectrum Condition: A Qualitative Exploration of the 'Family Dog Service'.

Evidence suggests that assistance and therapy dogs can positively impact the mental and physical health of children with autism spectrum condition (ASC) and their families. However, these services are often costly and inaccessible. As an alternative, companion dogs (e.