Publications by authors named "C M Mermier"
Introduction: A bout of vigorous endurance exercise transiently activates Toll-like receptor 4 (TLR4) and reduces TLR4 protein expressed on peripheral blood mononuclear cells (PBMCs). Endurance training, on the other hand, reduces TLR4-mediated signaling and minimizes the physiological stress imposed by exercise. Less is known about what occurs in skeletal muscle regarding TLR4 regulation and signaling.
View Article and Find Full Text PDFA rise in body temperature caused by physical work, including exercise, in a hot climate can lead to heat-related illnesses such as exertional heat exhaustion and stroke. Individuals who work physically demanding occupations in hot environments are at heightened risk of heat injury. The mechanisms that contribute to heat illness resulting from physical work in the heat are complex and include dehydration, tissue ischemia and damage, oxidative stress, and inflammatory events.
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- Type 2 diabetes (T2D) and prediabetes impact both individuals and society, with poor glycemic control being a major issue that can potentially be improved through resistance exercise.
- The study aims to explore how varying levels of effort during resistance exercise sessions affect glycemic control and psychological responses in individuals with prediabetes or T2D.
- This research will include a crossover design where 15 participants will experience three different sessions: two exercise sessions (one high-effort and one low-effort) and a control session with no exercise, measuring both glycemic levels and psychological outcomes throughout the process.
The biphasic activity of autophagy and heat shock protein response in peripheral blood mononuclear cells following acute resistance exercise in resistance-trained males.
Eur J Appl Physiol
October 2024
Purpose: Autophagy and heat shock protein (HSP) response are proteostatic systems involved in the acute and adaptive responses to exercise. These systems may upregulate sequentially following cellular stress including acute exercise, however, currently few data exist in humans. This study investigated the autophagic and HSP responses to acute intense lower body resistance exercise in peripheral blood mononuclear cells (PBMCs) with and without branched-chain amino acids (BCAA) supplementation.
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- The study investigates whether maternal exercise can protect offspring from high-altitude pulmonary hypertension (PH) resulting from chronic hypoxic conditions, simulating high-altitude environments.
- Female mice were assigned to exercise or non-exercise groups during pregnancy, and their offspring were either kept at low altitude or exposed to hypoxia, with various health metrics assessed after eight weeks.
- Results showed that hypoxia led to smaller body sizes, reduced motor function, and PH signs in offspring, but maternal exercise did not significantly mitigate these effects, indicating the need for further research for conclusive findings.