Publications by authors named "C M McPherson"
Objectives: Skeletal indicators of developmental stress are commonly used to assess health, disease, and patterns of morbidity and mortality in past populations. Incorporating information about individual life history, such as adverse life events, allows for a more thorough understanding of their etiology. This paper adopts the double lens of ontogeny and the life course to analyze indicators of developmental stress in relation to known individual pathologies and developmental patterns of the cranium, vertebrae, and long bones.
View Article and Find Full Text PDFAberrant activation of NLRP3 due to persistent tissue damage, misfolded proteins or crystal deposits has been linked to multiple chronic inflammatory disorders such as cryopyrin-associated periodic syndrome (CAPS), neurodegenerative diseases, gouty arthritis, and numerous others. Hence, there has been an increasing interest in NLRP3 inhibitors as therapeutics. A first generation of NLRP3 inhibitors bearing a sulfonylurea core such as MCC950 (developed by Pfizer) were discovered by phenotypic screening, however their mode of action was only elucidated later.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates how experiencing stressors, like illnesses during prenatal and birth stages, affects growth and height in children, focusing on stunted stature at the time of death.
- Data was collected from a pediatric dataset of individuals aged 0-20.9 years who died in New Mexico, examining the effects of prenatal stress, postnatal stress severity, and socioeconomic factors on growth outcomes.
- Results show that moderate to severe illnesses before age 12 increase the likelihood of stunting, while prenatal or birth issues were linked to younger age at death, indicating a need for prolonged severe stressors to develop stunting.
Background: Neonatal Intensive Care Units utilize incubators to sustain core temperatures associated with transepidermal water loss. High relative humidity in incubators provides an environment for fungi to grow. In August 2022, mold was identified growing in 11 (85%) Neonatal Intensive Care Unit incubators.
View Article and Find Full Text PDFObjective: This study aimed to evaluate cardiorespiratory status in preterm infants receiving dexmedetomidine using high-resolution physiologic data.
Study Design: We analyzed preterm infants with continuous heart rate (HR) and oxygen saturation (SpO) data for 24 hours preceding and 48 hours following dexmedetomidine initiation. Invasive arterial blood pressure (ABP), when available, was analyzed.