Effects of mechanical stimulation on metabolomic profiles of SW1353 chondrocytes: shear and compression.

Mechanotransduction is a biological phenomenon where mechanical stimuli are converted to biochemical responses. A model system for studying mechanotransduction are the chondrocytes of articular cartilage. Breakdown of this tissue results in decreased mobility, increased pain, and reduced quality of life.

Attitudes Towards Mental Health Services During the COVID-19 Pandemic: Findings from a Nationally Representative Sample of Irish Adults.

This study sought to determine the public's attitudes towards mental health services during the COVID-19 pandemic and examine the sociodemographic and psychological factors associated with these attitudes to gain an understanding of the best course of action to increase favourable attitudes. Data from the Republic of Ireland arm of the COVID-19 Psychological Research Consortium (C19PRC) study was used to fulfil the objectives of this study. Participants were asked to indicate their level of agreement with statements regarding mental health services and the COVID-19 pandemic.

Metabolic responses induced by compression of chondrocytes in variable-stiffness microenvironments.

Cells sense and respond to mechanical loads in a process called mechanotransduction. These processes are disrupted in the chondrocytes of cartilage during joint disease. A key driver of cellular mechanotransduction is the stiffness of the surrounding matrix.

Combining Targeted Metabolomic Data with a Model of Glucose Metabolism: Toward Progress in Chondrocyte Mechanotransduction.

Osteoarthritis is a debilitating disease likely involving altered metabolism of the chondrocytes in articular cartilage. Chondrocytes can respond metabolically to mechanical loads via cellular mechanotransduction, and metabolic changes are significant because they produce the precursors to the tissue matrix necessary for cartilage health. However, a comprehensive understanding of how energy metabolism changes with loading remains elusive.