Ex Vivo, In Vitro and In Vivo Bone Health Properties of Grana Padano Cheese.

Grana Padano (GP) is an Italian hard cooked cheese characterized by a long ripening process and high protein and Ca contents. After in vitro static simulated gastrointestinal digestion, GP digest contained caseinophosphopeptides that were 6 to 24 amino acids in length, including tri-phosphorylated species incorporating the pSer-pSer-pSer-Glu-Glu cluster. Using rat ileum tissue, the digest was used to assess Ca absorption ex vivo, which showed significantly better results for the GP digest in comparison to the CaCO aqueous solution.

V-ATPase in glioma stem cells: a novel metabolic vulnerability.

Background: Glioblastoma (GBM) is a lethal brain tumor characterized by the glioma stem cell (GSC) niche. The V-ATPase proton pump has been described as a crucial factor in sustaining GSC viability and tumorigenicity. Here we studied how patients-derived GSCs rely on V-ATPase activity to sustain mitochondrial bioenergetics and cell growth.

Impact of developmental temperature on neural growth, connectivity, and function.

Environmental temperature dictates the developmental pace of poikilothermic animals. In , slower development at lower temperatures results in higher brain connectivity, but the generality of such scaling across temperatures and brain regions and its impact on function are unclear. Here, we show that brain connectivity scales continuously across temperatures, in agreement with a first-principle model that postulates different metabolic constraints for the growth of the brain and the organism.

Hepatic artery aneurysm with no proximal neck and proper hepatic artery bifurcation involvement.

We report the case of a patient with a saccular aneurysm of the hepatic artery with maximum diameter of 2.8 cm, no proximal neck, and involving the bifurcation of the proper hepatic artery, constituting a hostile anatomy for endovascular treatment, which would usually be the first choice for such cases. We performed open surgical treatment with resection and reconstruction using an autologous graft (internal saphenous vein).

Multilayer Structure Damage Detection Using Optical Fiber Acoustic Sensing and Machine Learning.

Over the past decade, distributed acoustic sensing has been utilized for structural health monitoring in various applications, owing to its continuous measurement capability in both time and space and its ability to deliver extensive data on the conditions of large structures using just a single optical cable. This work aims to evaluate the performance of distributed acoustic sensing for monitoring a multilayer structure on a laboratory scale. The proposed structure comprises four layers: a medium-density fiberboard and three rigid polyurethane foam slabs.