Publications by authors named "C M Lowndes"
Article Synopsis
- Novel STI prevention methods like doxycycline post-exposure prophylaxis (doxyPEP) and meningococcal B vaccination (4CMenB) are being explored to help control STIs, especially among men and gender-diverse individuals in the UK.
- A survey involving 1,106 participants found that only 34% were aware of antibiotic PEP, with just 8% having reported ever using it; however, 51% expressed an intention to use doxyPEP and 64% for 4CMenB.
- Higher rates of PEP usage and intention to use doxyPEP and 4CMenB were associated with higher sexual risk behaviors and participants who were already using other preventative measures like
Confined cell migration hampers genome integrity and activates the ATR and ATM mechano-transduction pathways. We investigated whether the mechanical stress generated by metastatic interstitial migration contributes to the enhanced chromosomal instability observed in metastatic tumor cells. We employed live cell imaging, micro-fluidic approaches, and scRNA-seq to follow the fate of tumor cells experiencing confined migration.
View Article and Find Full Text PDFBackground: The treatment landscape for relapsing multiple sclerosis (MS) has changed dramatically in recent decades, including an increasing number of high-efficacy disease-modifying therapies (DMTs) with varied administration and monitoring requirements. Coupled with greater focus on earlier treatment, these factors have resulted in stretching of the capacity of MS specialist services and allied healthcare professionals (HCPs). To assist with the effective planning of MS services in the UK NHS, this study quantified the administration and monitoring time burden associated with high-efficacy DMTs (alemtuzumab, cladribine tablets, fingolimod, natalizumab, and ocrelizumab) for relapsing MS.
View Article and Find Full Text PDFTh17 cells increase in RRMS as well as in SPMS, whereas various other phenotypes of Th17 increase in RRMS only.
Mult Scler J Exp Transl Clin
January 2020
Background: The nature and extent of inflammation seen in multiple sclerosis (MS) varies throughout the course of the disease. Changes seen in CD4+ T-helper cells in relapsing-remitting (RR) MS and secondary progressive (SP) MS might differ qualitatively and/or quantitatively.
Objective: The objective of this paper is to study the frequencies of all major CD4+ T-helper subtypes - Th17, Th22 and Th1 lineage cells - in relapse, remission and secondary progression alongside CCR6 status, a chemokine receptor involved in migration of these cells into the central nervous system.