Publications by authors named "C M Libetta"
Article Synopsis
- Uremic retention solutes can trigger apoptosis in various cell types, including peripheral blood mononuclear leukocytes (PBL), which may lead to immune problems and low white blood cell counts in kidney disease patients.* -
- The study revealed that uremic PBL exhibited decreased cell survival and increased death rates when exposed to high molecular weight components of uremic plasma, impacting both healthy and diseased PBL and mononuclear cell lines.* -
- The findings suggest that these solutes disrupt cellular processes like endocytosis and proteostasis, activating stress responses and apoptosis pathways in immune cells, a phenomenon termed the immuno-proteostasis response of uremia.*
CD73-Adenosinergic Axis Mediates the Protective Effect of Extracellular Vesicles Derived from Mesenchymal Stromal Cells on Ischemic Renal Damage in a Rat Model of Donation after Circulatory Death.
Int J Mol Sci
September 2022
Article Synopsis
- The study introduces a new approach to organ conditioning using mesenchymal stromal cells (MSCs) and extracellular vesicles (EVs) during kidney preservation at low temperatures.
- It highlights that the CD73 marker on renal cells helps protect against damage caused by lack of blood flow, specifically by converting adenosine monophosphate to adenosine.
- Findings indicate that kidneys treated with MSCs or EVs exhibited less damage and better cell growth compared to those treated with CD73-silenced EVs, showing that these treatments enhance kidney resilience against ischemic injury.
Patients with severe COVID-19 both seroconvert earlier and develop higher concentrations of SARS- CoV-2-specific IgG than patients with mild symptoms. In this retrospective study we considered different categories of patients defined as "vulnerable" because affected by other pathologies, such as patients with genetic and cardiovascular diseases; patients with autoimmune dermatological dis- ease; kidney and lung transplant patients, and pregnant women because the prevalence of Covid-19 infection during pregnancy is not known. This study was performed at IRCCS San Matteo Hospital in Pavia, North Italy, a zone considered at high risk during the COVID-19 pandemic from June to December 2020.
View Article and Find Full Text PDFExtracellular Vesicles Derived from Mesenchymal Stromal Cells Delivered during Hypothermic Oxygenated Machine Perfusion Repair Ischemic/Reperfusion Damage of Kidneys from Extended Criteria Donors.
Biology (Basel)
February 2022
The poor availability of kidney for transplantation has led to a search for new strategies to increase the donor pool. The main option is the use of organs from extended criteria donors. We evaluated the effects of hypothermic oxygenated perfusion (HOPE) with and without extracellular vesicles (EV) derived from mesenchymal stromal cells on ischemic/reperfusion injury of marginal kidneys unsuitable for transplantation.
View Article and Find Full Text PDFKidney Transplants From Donors on Extracorporeal Membrane Oxygenation Prior to Death Are Associated With Better Long-Term Renal Function Compared to Donors After Circulatory Death.
Transpl Int
March 2022
Donation after circulatory death (DCD) allows expansion of the donor pool. We report on 11 years of Italian experience by comparing the outcome of grafts from DCD and extracorporeal membrane oxygenation (ECMO) prior to death donation (EPD), a new donor category. We studied 58 kidney recipients from DCD or EPD and collected donor/recipient clinical characteristics.
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