Exchange of Clinical and Omics Data According to FAIR Principles: A Review of Open Source Solutions.

Background: Due to the ongoing increase and importance of the sustainable reusability of data, the findable, accessible, interoperable, reusable or FAIR principles were developed which are also relevant in translational research.

Objectives: The study aims at identification of platforms by literature search that are suitable for implementation in translational research, in particular with regard to their FAIRness.

Methods: The collected information is summarized and compared.

Pan-European Data Harmonization for Biobanks in ADOPT BBMRI-ERIC.

Background: High-quality clinical data and biological specimens are key for medical research and personalized medicine. The Biobanking and Biomolecular Resources Research Infrastructure-European Research Infrastructure Consortium (BBMRI-ERIC) aims to facilitate access to such biological resources. The accompanying ADOPT BBMRI-ERIC project kick-started BBMRI-ERIC by collecting colorectal cancer data from European biobanks.

Developing New Analysis Functions for a Translational Research Platform: Extending the cBioPortal for Cancer Genomics.

Background: The cBioPortal is a prevalent open-source translational research platform, allowing private instances and extensions.

Objective: Our aim was to build up an own instance of cBioPortal, identify missing functionality by interviewing researchers, and implementing these extensions.

Methods: We examined the code base of the cBioPortal and conducted a requirements analysis with researchers.

Samply.MDR - A Metadata Repository and Its Application in Various Research Networks.

Collaboration in medical research is becoming common, especially for collecting relevant cases across institutional boundaries. If the data, which is usually very heterogeneously formalized and structured, can be integrated, such a collaboration can facilitate research. An absolute prerequisite for this is an extensive description about the formalization and exact meaning of every data element contained in a dataset.

Usability and Suitability of the Omics-Integrating Analysis Platform tranSMART for Translational Research and Education.

Background: Platforms like tranSMART assist researchers in analyzing clinical and corresponding omics data. Usability is an important, yet often overlooked, factor affecting the adoption and meaningful use. Analyses on the specific needs of translational researchers and considerations about the application of such platforms for education are rare.