Publications by authors named "C M Klapperich"
Airway smooth muscle (ASM) cells play important roles in airway remodeling of asthma. Our previous studies show that in vivo administration of glial-derived neurotrophic factor (GDNF) in mice induces thickening and collagen deposition in bronchial airways, whereas chelation of GDNF by GFRα1-Fc attenuates airway remodeling in the context of allergen exposure. To determine whether GDNF has direct effects on ASM, in this study, we examined GDNF in ASM cells from normal versus asthmatic humans.
View Article and Find Full Text PDFErratum for Brown-Elliott et al., "Emergence of Inducible Macrolide Resistance in Due to Broad-Host-Range Plasmid and Chromosomal Variants of the Novel 23S rRNA Methylase Gene, (55)".
J Clin Microbiol
May 2024
Article Synopsis
- Curable STIs can lead to poor pregnancy outcomes, but current diagnostic methods often miss asymptomatic cases due to their limitations in sensitivity and specificity.
- Researchers developed new DNA amplification primers using an innovative algorithm to improve diagnostic assays for STIs.
- The new IMRS-PCR assay demonstrated superior sensitivity compared to traditional methods and can be adapted for use in portable diagnostic devices, enhancing STI detection in pregnant women.
Article Synopsis
- In-person learning at universities resumed in 2021 despite high SARS-CoV-2 spread, raising concerns about potential disease transmission on campus.! -
- Researchers used testing, contact tracing, and viral genome sequencing to analyze how the virus spread within university settings, finding that most viral strains didn't lead to further transmission.! -
- The study concluded that public health measures effectively limited virus spread inside universities, with only two significant outbreaks occurring during a specific period, highlighting the success of test-trace-isolate strategies in managing outbreaks.
Emergence of Inducible Macrolide Resistance in Mycobacterium chelonae Due to Broad-Host-Range Plasmid and Chromosomal Variants of the Novel 23S rRNA Methylase Gene, (55).
J Clin Microbiol
July 2023
Macrolides are a mainstay of therapy for infections due to nontuberculous mycobacteria (NTM). Among rapidly growing mycobacteria (RGM), inducible macrolide resistance is associated with four chromosomal 23S rRNA methylase () genes. Beginning in 2018, we detected high-level inducible clarithromycin resistance (MICs of ≥16μg/mL) in clinical isolates of Mycobacterium chelonae, an RGM species not previously known to contain genes.
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