Differences in binding affinities of MDA, MDMA, MDEA, Amphetamine, Methamphetamine, and their deuterated analogues to solid-phase extraction cartridges.

This study evaluated the potential for partial separation of drugs from their deuterated internal standards using Cerex(®) Polycrom™ CLIN II solid-phase extraction (SPE) cartridges. After elution from the column and derivatization, gas chromatography-mass spectrometry results showed that the target compound eluted from the SPE cartridge prior to its deuterated form. This elution separation effect was greater for 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (MAMP) than for the other drugs studied.

Rapid quantification of urinary oxycodone and oxymorphone using fast gas chromatography-mass spectrometry.

Human urine specimens that were determined to be presumptively positive for oxycodone and its metabolite, oxymorphone, by immunoassay screening were assayed using fast gas chromatography-mass spectrometry to positively identify and quantify the oxycodone and oxymorphone present. Urine specimens were first spiked with deuterated internal standards, oxycodone-d(3) and oxymorphone-d(3), subjected to acid hydrolysis, and then extracted using a positive-pressure manifold and mixed-bed solid-phase cartridge extraction methodology. Extracts were derivatized using methoxylamine and acetic anhydride.

Stability of fluconazole in injectable solutions.

The stability of fluconazole 1 mg/mL in several injectable solutions at 25 degrees C over 72 hours was studied. Fluconazole 2 mg/mL was mixed in a 1:1 ratio with 5% dextrose injection, lactated Ringer's injection, potassium chloride 20 meq/L in 5% dextrose injection, heparin sodium 100 units/mL in 5% dextrose injection, theophylline 0.8 mg/mL in 5% dextrose injection, and morphine sulfate 0.