Publications by authors named "C M Graf"
Human papillomavirus (HPV) infections drive one in 20 new cancer cases, exerting a particularly high burden on women. Most anogenital HPV infections are cleared in less than two years, but the underlying mechanisms that favour persistence in around 10% of women remain largely unknown. Notwithstanding, it is precisely this information that is crucial for improving treatment, screening, and vaccination strategies.
View Article and Find Full Text PDFBackground: We studied the duration of HPV detection and risk of (re-) detection for 25 HPV genotypes in a cohort of 132 women followed every eight weeks for up to two years between 2016 and 2020. Participants were between 18 and 25 years old at inclusion and half of them were vaccinated against HPV. They were recruited near the University and the STI detection centre in Montpellier, France.
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- The study aimed to investigate how smoking exposure is linked to organ damage in patients with systemic lupus erythematosus (SLE) using a specific damage score (SLICC-SDI) in an Argentinian cohort.
- Out of 623 SLE patients analyzed, 84% were non-smokers, while 16% were current smokers, with 17% showing severe organ damage (SLICC-SDI ≥3).
- The findings indicated that current smoking, older age, longer disease duration, and the use of cyclophosphamide are significantly associated with severe organ damage in SLE patients.
Purpose: This study aimed to develop a hyperosmolar, barrier-forming nasal spray based on carrageenan and sorbitol, and to demonstrate its decongestant effect in the context of allergic rhinitis (AR).
Methods: The efficacy of the nasal spray components was tested in vitro by barrier function, virus replication inhibition, and water absorption assays. The decongestant effectiveness was assessed in a randomized, controlled, crossover environmental chamber trial, where participants with a history of seasonal grass pollen AR were exposed to grass pollen allergens under controlled conditions.