Publications by authors named "C M Goodall"
Traditional etherification methods, although staples in synthetic chemistry, often fall short in the efficient construction of sterically hindered dialkyl ethers, especially under mild and practical conditions. Recent advances have attempted to address these limitations, typically relying on transition metal catalysts, external reductants, or harsh reaction conditions. In this work, we disclose a novel electrochemical approach that enables the synthesis of sterically hindered ethers from economically relevant and readily accessible alcohols without the need for sacrificial oxidants.
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- Patients facing social deprivation and related challenges like violence, substance misuse, and homelessness often have higher emergency department (ED) usage, prompting a need for effective interventions during ED visits.
- This study aims to evaluate the impact of the Navigator social support program, initiated during ED visits, on reducing healthcare use such as emergency and outpatient services over the following year.
- Using a retrospective analysis of patients in the West of Scotland from 2016 to 2023, the study compares healthcare use rates before and after the intervention to assess changes resulting from the Navigator program.
Synthesis of core-functionalised naphthalene diimides from naphthalenetetracarboxylic dianhydride using a vibratory ball mill: bromination, imidization and Heck-type reactions.
Chemistry
November 2024
Article Synopsis
- Researchers developed a new method to synthesize 9 core-functionalised naphthalene diimide (c-NDI) compounds using a three-step, solvent-free process that activates chemicals mechanically.
- They achieved selective dibromination of naphthalenetetracarboxylic dianhydride in a vibratory ball mill, producing a key intermediate (2,6-dibromonaphthalenediimide) quickly and efficiently within 5 hours, significantly faster than traditional methods.
- The study also successfully executed rapid Heck-type cross coupling reactions with various styrene residues, resulting in good yields of c-NDIs without the need for extra heating or solvents, making the process robust against environmental conditions.
In this letter, we disclose the anodic oxidation of oxamic acids in the presence of EtN·3HF as a practical, scalable, and robust method to rapidly access carbamoyl fluorides from readily available and stable precursors. The simplicity of this method also led us to develop the first flow electrochemical preparation of carbamoyl fluorides, demonstrating scale-up feasibility as a proof of concept.
View Article and Find Full Text PDFThe human immunodeficiency virus (HIV)-encoded accessory protein Nef enhances pathogenicity by reducing major histocompatibility complex I (MHC-I) cell surface expression, protecting HIV-infected cells from immune recognition. Nef-dependent downmodulation of MHC-I can be reversed by subnanomolar concentrations of concanamycin A (), a well-known inhibitor of vacuolar ATPase, at concentrations below those that interfere with lysosomal acidification or degradation. We conducted a structure-activity relationship study that assessed 76 compounds for Nef inhibition, 24 and 72 h viability, and lysosomal neutralization in Nef-expressing primary T cells.
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