Publications by authors named "C M Gant"
Article Synopsis
- A 39-year-old woman diagnosed with relapsing nephrotic syndrome was found to have cryofibrinogen and a monoclonal immunoglobulin (M-protein) in her blood, indicating monoclonal gammopathy related to kidney issues.
- Initial immunosuppressive treatment led to temporary improvement, but after her condition relapsed, she underwent more intensive therapy, including stem cell transplantation, which again provided temporary relief.
- Subsequent experiments revealed that the cryoactivity was dependent on the M-protein, suggesting that cryofibrinogenemia is linked to this protein and should be associated with monoclonal gammopathy of renal significance.
Objective: Pharmacological inhibition of the renin-angiotensin-aldosterone-system (RAASi) is the cornerstone of hypertension treatment, renoprotection and secondary prevention of cardiovascular disease in patients with type 2 diabetes. Although there is a dose-dependent effect of RAASi with optimum protection when using maximal dose, little is known on actual use of maximal dosage RAASi in clinical practice. Here we investigate prevalence of maximal dosage RAASi, and contraindications for, optimizing RAASi dosage, in patients with complicated type 2 diabetes in a real-life clinical setting.
View Article and Find Full Text PDFBackground: Low 24-h urinary potassium excretion, reflecting low potassium intake, is associated with premature mortality in the general population.
Objectives: To determine whether urinary potassium excretion is associated with all-cause mortality in patients with type 2 diabetes.
Methods: We performed a prospective cohort study in 654 patients with type 2 diabetes in the Diabetes and Lifestyle Cohort Twente (DIALECT).
Adherence to Statin Therapy and Attainment of LDL Cholesterol Targets in an Outpatient Population of Type 2 Diabetes Patients: Analysis in the DIAbetes and LifEstyle Cohort Twente (DIALECT).
Front Pharmacol
July 2022
To assess adherence to statin therapy and its association with sociodemographic data, medical characteristics, LDLc levels, and LDLc target attainment in real-world T2D patients treated in secondary care. Cross-sectional analyses were performed on baseline data of 393 patients in the DIAbetes and LifEstyle Cohort Twente (DIALECT). The medication possession ratio (MPR), calculated with pharmacy dispensing data, was used to determine adherence to statins for an intended period of 24 months.
View Article and Find Full Text PDF[An asymptomatic patient with lactate acidosis and hypercapnia].
Ned Tijdschr Geneeskd
September 2021
Background: Blood gas analyses are used to identify acid-base and respiratory disturbances. Blood gas abnormalities can be first signs of serious underlying disease.
Case Description: An 82-year old women with chronic kidney disease (eGFR 35 ml/min/1.