Publications by authors named "C M Galambos"

Congenital pulmonary airway malformations (CPAMs) are cystic lung lesions often detected prenatally. Resection is often recommended for potential recurrent infections and malignancy. This report describes a case of a 14-year-old female patient who presented with abdominal pain.

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Pulmonary veno-occlusive disease (PVOD) is a lethal variant of pulmonary hypertension. The degree of pulmonary arterial involvement varies. Here, we compare two PVOD patients who were transplanted at 8 years of age, whereof one is a homozygous mutation carrier.

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Urine serotonin (5-HT)/creatinine was lower at day of life 3 in newborns with pulmonary hypertension compared with controls, while the percent change in the 5-HT metabolite, 5-hydroxyindoleacetic acid (5-HIAA)/creatinine increased. We speculate that the changes in 5-HT and 5-HIAA reflect enhanced pulmonary 5-HT uptake and/or metabolism.

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Article Synopsis
  • Diverse genetic respiratory disorders can lead to severe pulmonary hypertension (PH) in newborns, but there are still many unresolved questions about the best ways to diagnose and manage these conditions for better long-term results.
  • A multidisciplinary team of pediatric specialists has come together to tackle the current challenges in clinical approaches and support for families of infants with developmental lung disease (DEVLD).
  • The review discusses the clinical features of infants with DEVLD/DEVLD-PH, highlights decision-making complexities such as genetic testing and imaging, and stresses the need for teamwork, communication, and comprehensive counseling for families.
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