Publications by authors named "C M Ewing"
Background: The risks of postoperative complications in breast cancer patients vary by patient and tumor characteristics. Elevated BMI and invasive lobular carcinoma (ILC) increase risks of surgical complications and positive margins, respectively.
Methods: We retrospectively analyzed patients with BMI ≥30 kg/m from an institutional ILC database.
Article Synopsis
- - The study aimed to understand MRI imaging patterns in breast cancer patients undergoing neoadjuvant immunotherapy, particularly focusing on responses to various combinations of chemotherapy and immunotherapy in the I-SPY2 clinical trial.
- - Out of 43 patients analyzed, 44.4% receiving the chemo-immunotherapy experienced increased lymphadenopathy in the first 12 weeks, significantly higher compared to just 6.3% in the control group, with most cases linked to the SD-101 and pembrolizumab treatment.
- - Despite observing increased lymphadenopathy in some patients, this was not associated with a higher incidence of positive lymph nodes at surgery, even as breast tumor sizes decreased over time.
Among the goals of patient-centric care are the advancement of effective personalized treatment, while minimizing toxicity. The phase 2 I-SPY2.2 trial uses a neoadjuvant sequential therapy approach in breast cancer to further these goals, testing promising new agents while optimizing individual outcomes.
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- - In late 2022 and early 2023, CAL FIRE tree health experts assessed four maple trees in Elk Grove, California, which were in severe decline, exhibiting thinning canopies and visible bark damage due to cankers filled with fungi.
- - Laboratory analysis from the affected trees identified cultures of the fungus Cryptostroma corticale, using DNA sequencing techniques that confirmed its identity against a database of known organisms.
- - The study aimed to understand the extent of the fungal infection and the health issues affecting these exotic maple species, raising concerns about their viability in the California environment.
Background: Invasive lobular carcinoma (ILC) of the breast is known for high risk of late recurrence, yet some patients still recur within 5 years of diagnosis. Determining factors associated with early/late recurrence could help tailor treatment and surveillance strategies.
Methods: Using an institutional database, we evaluated patients with ILC and ≥ 5 years of follow-up or recurrence within 5 years.