Publications by authors named "C M Evelyn"
With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833 (M-833), that inhibited the ring-stage development of newly invaded merozoites. Here, we select parasites resistant to M-833 and identify mutations in the START lipid transfer protein (PF3D7_0104200, PfSTART1).
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- The most severe malaria is caused by Plasmodium falciparum, which invades red blood cells using a specific complex that involves a protein called PfRh5 and its interacting partners.
- Researchers discovered a new complex made of PfPTRAMP and PfCSS that aids in this invasion process, demonstrating its critical role using advanced microscopy and genetic techniques.
- The study reveals the structure of the complex and identifies key targets for vaccine development, aiming to create effective strategies to combat malaria during its blood stage.
Tryptophan C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR) domain in metazoans. Here we show that Plasmodium falciparum expresses a DPY19 tryptophan C-mannosyltransferase in the endoplasmic reticulum and that DPY19-deficiency abolishes C-glycosylation, destabilizes members of the TRAP adhesin family and inhibits transmission to mosquitoes. Imaging P.
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