Publications by authors named "C M Crespi"
Background: The relationship between community-based healthcare barriers and risk of recurrent hospital-based care among persons with chronic liver disease (CLD) is understudied. We aimed to uncover distinct groups among adults in the United States with CLD based on healthcare barriers and risk-stratify recurrent acute care use by group.
Methods: Using National Health Interview Survey (2011 to 2017) data, we performed latent class analysis (LCA) to uncover groups experiencing distinct sets of healthcare barriers.
Objective: We assessed the performance of ICD codes to identify patients with hepatocellular carcinoma (HCC) in a large academic health system and determined whether employing an algorithm using a combination of ICD codes could deliver higher accuracy and precision than single ICD codes in identifying HCC cases using electronic health record (EHR) data.
Results: The use of a single ICD code entry for HCC (ICD-9-CM 155.0 or ICD-10-CM C22.
Maternal ingestion of cannabidiol (CBD) in mice leads to sex-dependent changes in memory, anxiety, and metabolism in the adult offspring, and causes a decrease in survival to weaning age.
Pharmacol Biochem Behav
October 2024
Article Synopsis
- The study investigates the health, metabolic, and behavioral impacts of perinatal cannabidiol (CBD) exposure on female mice and their offspring into adulthood, highlighting the lack of research on this widely used supplement.
- Results indicate that maternal CBD exposure can negatively affect offspring survival and postnatal development, particularly in males, while also producing various sex-dependent metabolic and behavioral changes in adults.
- The findings suggest CBD exposure during pregnancy and lactation influences behaviors such as anxiety and obsessive-compulsive traits, with significant implications for understanding the safety and effects of CBD use during pregnancy.
Article Synopsis
- A study conducted in Kenya aimed to identify factors influencing HPV vaccination rates among preadolescent girls, revealing that many parents lack knowledge and hold hesitations regarding the vaccine.
- Survey results showed that 38.2% of parents reported that their eligible daughters received at least one dose of the HPV vaccine, with higher vaccination rates linked to increased knowledge and trust in health institutions.
- Access to vaccination services was a significant barrier, as those facing challenges were half as likely to have vaccinated daughters compared to those with better access.
Background: The purpose of this study was to examine the impact of breast cancer therapy on biological aging as measured by expression of genes for cellular senescence (p16INK4a, SenMayo), DNA damage response, and proinflammatory senescence-associated secretory phenotype.
Methods: This longitudinal, observational study evaluated women diagnosed with breast cancer (stage 0-III) prior to radiation therapy (RT) and/or chemotherapy (CT) and at repeated visits out to 2 years. Peripheral blood mononuclear cell gene expression was assessed using RNA sequencing on quality-verified RNA.