Publications by authors named "C M Ciniselli"
Background: Familial adenomatous polyposis is a cancer-predisposing syndrome caused by germline pathogenic variants of the adenomatous polyposis coli gene, leading to numerous colorectal polyps and a high risk of colorectal cancer. Desmoid tumours have become significant in the management of familial adenomatous polyposis after a colectomy, yet the exact incidence remains undetermined due to a lack of dedicated surveillance.
Methods: This retrospective study accessed data from the prospectively maintained Hereditary Digestive Tumours Registry from 2000 to 2023.
Article Synopsis
- The study addresses the growing concern of cardiovascular diseases (CVDs) among adolescent and young adult (AYA) survivors of breast cancer due to the cardiotoxic effects of cancer treatments.
- Researchers developed a Bayesian network model using data from over a thousand young female BC survivors to predict CVD risk, achieving strong classification performance and clear causal relationships.
- An application was created to provide individual risk assessments for patients, aimed at helping clinicians personalize follow-up care for AYA BC survivors at higher risk of developing CVDs.
Few studies investigated the genetics of relapsed Wilms tumor (WT), suggesting the gene, the microRNA processing genes, and the MYCN network as possibly involved in a relevant percentage of relapses. We investigated 28 relapsing WT patients (10 new cases and 18 cases in which the involvement of and miRNAPG had been excluded) with a panel of ∼5000 genes. We identified variants affecting genes involved in DNA damage prevention and repair in 12/28 relapsing patients (42.
View Article and Find Full Text PDFBackground: Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer, with 5-10% of cases progressing into invasive disease. Herein, we investigated the association between HER2-low and clinico-pathological characteristics in DCIS and subsequent ipsilateral loco-regional relapse (LRR).
Materials And Methods: We accessed our prospectively maintained institutional database.
Background: We report on a series of consecutive patients with localized radiation-associated angiosarcoma (RAAS) of the breast region (BR) treated at two Italian sarcoma reference centers.
Materials And Methods: We retrospectively reviewed all cases of primary, localized, resectable RAAS of the BR, treated at one of the two participating institutions from 2000 to 2019. Relapse-free survival (RFS) and overall survival (OS) were calculated.