Publications by authors named "C M Canessa"
Article Synopsis
- Respiratory Syncytial Virus (RSV) is a leading cause of respiratory infections in young children, and the study aimed to explore how the SARS-CoV-2 pandemic affected RSV hospitalizations in kids.
- An analysis of children hospitalized for RSV from 2014 to 2023 revealed a significant increase in hospitalizations after the pandemic, particularly among older children, with 70% under one year old and many needing ICU care.
- Preventive strategies like Nirsevimab could have reduced hospitalizations by over 46%, and including older children with comorbidities could increase this prevention rate to more than 57%.
Article Synopsis
- Inborn errors of immunity (IEIs) are inherited disorders that significantly increase the risk of severe infections and other serious health issues, with early detection being crucial, especially for severe combined immunodeficiency in newborns.
- A study in Tuscany, Italy, assessed the effectiveness of an expanded newborn screening (NBS) strategy that used advanced assays to identify various IEIs in infants born between 2018 and 2022.
- The findings showed a referral rate consistent with existing literature and a diagnosis rate of 1 in 9431 newborns, marking a successful implementation of a real-life NBS program aimed at improving early intervention for affected infants.
Background: Hemophagocytic Lymphohistiocytosis (HLH) is a rare and life-threatening condition characterized by a severe impairment of the immune homeostasis. While Familial-HLH (FHL) is a known cause, the involvement of other Inborn Errors of Immunity (IEI) in pediatric-HLH remains understudied.
Objective: This systematic review aimed to assess the clinical features, triggers, laboratory data, treatment, and outcomes of pediatric HLH patients with IEI other than FHL (IEInotFHL), emphasizing the importance of accurate identification and management.
We report the case of a patient with common variable immunodeficiency (CVID) presenting with short stature and treated with recombinant human growth hormone (rhGH). Whole exome sequencing revealed a novel single-nucleotide duplication in the gene (c.904dup, p.
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