Publications by authors named "C M C van Campen"
H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the disialoganglioside GD2 (ref. ). Chimeric antigen receptor-modified T cells targeting GD2 (GD2-CART) eradicated DMGs in preclinical models.
View Article and Find Full Text PDFPurpose: Pharmacologic therapies for neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PNs) are limited; currently, none are US Food and Drug Administration-approved for adults.
Methods: ReNeu is an open-label, multicenter, pivotal, phase IIb trial of mirdametinib in 58 adults (≥18 years of age) and 56 children (2 to 17 years of age) with NF1-PN causing significant morbidities. Patients received mirdametinib capsules or tablets for oral suspension (2 mg/m twice daily, maximum 4 mg twice daily), regardless of food intake, in 3 weeks on/1 week off 28-day cycles.
Article Synopsis
- Artificial intelligence in medicine usually faces challenges related to small, non-diverse patient data due to privacy concerns, but federated learning (FL) offers a solution by allowing training across different hospitals without sharing sensitive data.
- The newly developed FL-PedBrain platform is specifically designed for pediatric brain tumors, enabling collaborative training for tumor classification and segmentation across 19 international centers, addressing the lack of diverse datasets in this area.
- FL-PedBrain shows impressive performance metrics, maintaining almost equivalent accuracy to centralized data training while significantly improving segmentation performance by 20 to 30% at external sites, and allows for the examination of data variability in real-world situations.
Eye tracking technology is a high-potential tool for different mathematic cognition research areas. Moreover, there is a dire need for more studies that provide detailed information on the quality of registered eye data. This study aimed to illustrate the applicability of eye tracking in the examination of mathematical cognition, focusing specifically on primary school students completing a computerized mental arithmetic task.
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