Publications by authors named "C M Bronner"
Background: The histone variant macroH2A (mH2A), the most deviant variant, is about threefold larger than the conventional histone H2A and consists of a histone H2A-like domain fused to a large Non-Histone Region responsible for recruiting PARP-1 to chromatin. The available data suggest that the histone variant mH2A participates in the regulation of transcription, maintenance of heterochromatin, NAD metabolism, and double-strand DNA repair.
Results: Here, we describe a novel function of mH2A, namely its implication in DNA oxidative damage repair through PARP-1.
Article Synopsis
- The study analyzed 5804 days of Super-Kamiokande data from 1996 to 2018 to detect variations in solar ^{8}B neutrino flux.
- The researchers utilized a five-day interval measurement approach and employed maximum likelihood and Lomb-Scargle methods to find any periodic modulations.
- They found a significant modulation related to Earth's elliptical orbit around the Sun, with measurements of eccentricity and perihelion shift aligning with astronomical data.
DNA methylation is one of the most important epigenetic mark involved in many physiologic cellular processes and pathologies. During mitosis, the transmission of DNA methylation patterns from a mother to the daughter cells is ensured through the action of the Ubiquitin-like, containing PHD and RING domains, 1/DNA methyltransferase 1 (UHRF1/DNMT1) tandem. UHRF1 is involved in the silencing of many tumor suppressor genes (TSGs) via mechanisms that remain largely to be deciphered.
View Article and Find Full Text PDFHIRIP3 is a mammalian protein homologous to the yeast H2A.Z deposition chaperone Chz1. However, the structural basis underlying Chz's binding preference for H2A.
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- Inherited defects in the MBD4 gene increase the risk for adenomatous polyposis and colorectal cancer by causing a specific type of DNA damage known as C > T transitions.
- Research shows that MBD4 plays a crucial role in maintaining DNA methylation and repairing G/T mismatches, with its absence leading to widespread hypomethylation and transcriptional changes in genes and repetitive elements.
- The study concludes that MBD4 is essential for correcting deaminated 5-methylcytosines, highlighting its importance in protecting DNA from methylation-related damage in both healthy and diseased states.