Publications by authors named "C M Barbagallo"
Male infertility is a risk factor for the development of testicular germ cell tumors. In this study, we investigated microRNA profiles in seminal plasma to identify potential noninvasive biomarkers able to discriminate the men at highest risk of developing cancer among the infertile population. We compared the microRNA profiles of individuals affected by testicular germ cell tumors and healthy individuals with normal or impaired spermiograms using high-throughput technology and confirmed the results by single-assay digital PCR.
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- Non-coding RNAs (ncRNAs) play a significant role in regulating cellular processes, and their altered expression is linked to prostate cancer (PCa), affecting disease initiation and response to treatment.
- This study focused on evaluating the effectiveness of specific RNAs, particularly miRNAs, in differentiating PCa from benign prostatic hyperplasia (BPH) using unfiltered urine samples from 100 patients.
- The findings indicated that certain miRNAs (like miR-27b-3p and miR-574-3p) are more reliable biomarkers for PCa than long RNAs, with combined miRNA profiles providing even better diagnostic accuracy, highlighting the potential of these non-invasive markers in clinical practice.
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- Lipoprotein(a) [Lp(a)] is identified as a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), with this study focusing on its levels among patients with different genetic dyslipidemias and the general population.
- The research involved various cohorts including hypercholesterolemic patients and free-living subjects, revealing that those with familial hypercholesterolemia (FH) had notably higher median Lp(a) levels compared to those with familial hypobetalipoproteinemia type 1 (FHBL1) and the general population.
- It was found that individuals at high cardiovascular (CV) risk have significantly elevated Lp(a) levels, suggesting that assessing Lp(a) in conjunction with
Objectives: Programmatic assessment approaches can be extended to the design of allied health professions training, to enhance the learning of trainees. The Australasian College of Physical Scientists and Engineers in Medicine worked with assessment specialists at the Australian Council for Educational Research and Amplexa Consulting, to revise their medical physics and radiopharmaceutical science training programs. One of the central aims of the revisions was to produce a training program that provides standardized training support to their registrars throughout the 3 years, better supporting their registrars to successfully complete the program in the time frame through providing timely and constructive feedback on the registrar's progression.
View Article and Find Full Text PDFIntrahepatic cholangiocarcinoma (iCCA) is recognized worldwide as the second leading cause of morbidity and mortality among primary liver cancers, showing a continuously increasing incidence rate in recent years. iCCA aggressiveness is revealed through its rapid and silent intrahepatic expansion and spread through the lymphatic system leading to late diagnosis and poor prognoses. Multi-omics studies have aggregated information derived from single-omics data, providing a more comprehensive understanding of the phenomena being studied.
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