Antibiotic chemoprophylaxis for close contacts of invasive group A streptococcus in community settings: evidence review.

Objectives: Revised UK guidelines for the management of contacts of invasive group A Streptococcus (iGAS) infection in community settings were published in December 2022. We present the findings of a narrative review which informed the public health recommendations around the provision of antibiotic chemoprophylaxis detailed in the updated guidelines.

Methods: We conducted a literature review of studies reporting the risk of iGAS infection associated with specific risk factors.

The development of a clinical practice guideline for the audiological management of infants and young children with permanent unilateral hearing loss using an integrated knowledge translation approach.

Objective: To describe the development and implementation of a management pathway for infants and young children identified with permanent unilateral hearing loss within an early hearing detection and intervention program in Ontario, Canada.

Design: An integrated knowledge translation approach was used to synthesise knowledge and generate a product: an updated clinical practice guideline. Current unilateral hearing loss guidelines were combined with the results of a scoping literature review focusing on technology options and outcomes for children with limited usable hearing unilaterally.

Transforming Brain Tumor Care: The Global Impact of Radiosurgery in Multidisciplinary Treatment Over Two Decades.

Background: Stereotactic radiosurgery, a minimally invasive treatment delivering high doses of radiation to a well-defined target, has transformed interdisciplinary treatment paradigms since its inception. This study chronicles its adoption and evolution for brain cancer and tumors globally.

Methods: A systematic literature review of SRS-focused articles from 2000 to 2023 was conducted.

Farm-based therapy: An innovative treatment approach for children, adolescents and young adults.

Purpose: To describe the rationale and components of Farm-based Therapy (FBT) as well as examine its preliminary efficacy.

Methods: FBT consists of five empirically supported components, or hands-on experience, sustainability, the life cycle, community, and mindfulness, that were developed in collaboration with clients, their caregivers, and clinicians. We explored the preliminary efficacy of FBT for improving anxiety and mood in new clients, and their parents, using the Revised Child Anxiety and Depression Scale (RCADS).

Integration of therapeutic cargo into the human genome with programmable type V-K CAST.

CRISPR-associated (Cas) transposases (CAST) are RNA-guided systems capable of programmable integration of large segments of DNA without creating double-strand breaks. Engineered Cascade CAST function in human cells but are challenging to deploy due to the complexity of the targeting components. Unlike Cascade, which require three Cas proteins, type V-K CAST require a single Cas12k effector for targeting.