Electroconvulsive therapy disrupts functional connectivity between hippocampus and posterior default mode network.

Background: The mechanisms underlying memory deficits after electroconvulsive therapy (ECT) remain unclear but altered functional interactions between hippocampus and neocortex may play a role.

Objectives: To test whether ECT reduces functional connectivity between hippocampus and posterior regions of the default mode network (DMN) and to examine whether altered hippocampal-neocortical functional connectivity correlates with memory impairment. A secondary aim was to explore if these connectivity changes are present 6 months after ECT.

Blood-brain barrier permeability and electroconvulsive therapy: a systematic review.

Objective: The cause of cognitive side effects after electroconvulsive therapy (ECT) is largely unknown. Alterations in the blood-brain barrier (BBB) have been considered in several recent ECT studies. We therefore found it worthwhile to perform a systematic review of the literature to examine if electrically induced seizures affect the permeability of the BBB.

Nature-Based Mindfulness: A Qualitative Study of the Experience of Support for Self-Regulation.

Self-regulation is pivotal for human well-being and mental health. In this qualitative study, we followed a randomized controlled trial (RCT) and explored how a five-day residential mindfulness program in a restorative natural setting supported self-regulation among university students experiencing moderate to severe stress. Six participants were interviewed post intervention and at three months' follow-up on how they experienced the retreat.

[Discontinuation of antidepressants].

Antidepressants are widely used. All antidepressants are associated with side effects, and in this review we therefore find it reasonable to reassess the indication for long-term use at least once a year. After remission of a depressive episode treatment should be continued for 6-9 months, and treatment should be continued longer for two years or more in the presence of risk factors for new depressive episodes.

Mechanisms in fluid retention - towards a mutual concept.

Fluid retention is a common and challenging condition in daily clinical practice. The normal fluid homoeostasis in the human body is based on accurately counter-balanced physiological mechanisms. When compromised fluid retention occurs and is seen in pathophysiologically different conditions such as liver cirrhosis, heart and kidney failure, and in preeclampsia.