Publications by authors named "C Luchini"
Background: Liquid biopsy (LB) is a laboratory test performed on a fluid sample aiming at analyzing molecular data derived from circulating cells and related entities, or from nucleic acids. This umbrella review aims to map and evaluate the evidence supporting the use of LB in medicine across different medical specialities and conditions.
Methods: We searched three repositories from database inception up to October 1, 2023 and we included meta-analyses of observational studies reporting data on the use of LB, compared to gold standard, and its accuracy (area under the curve, AUC).
Background: RAS/BRAF mutations, mismatch DNA repair complex deficiency (MMRd)/microsatellite instability (MSI), and CpG methylator phenotype (CIMP) are key molecular actors in colorectal carcinogenesis. To date, conflicting evidence about the correlations between these molecular features has been reported.
Materials And Methods: A retrospectively selected cohort of 123 CRCs was divided into 3 groups based on the molecular characteristics: MMR proficient (MMRp)/BRAF p.
Article Synopsis
- Fibroblast heterogeneity significantly impacts cancer progression, making it crucial to understand different fibroblast types for developing effective cancer treatments.
- In pancreatic ductal adenocarcinoma (PDAC), cancer-associated fibroblasts (CAFs) are the predominant cell type, and the study identifies how the MAPK signaling pathway influences their differentiation into specific phenotypes.
- The study introduces a novel "mapCAF" phenotype associated with certain tumor cells and immune response characteristics, suggesting that targeting these specific CAFs could improve treatment strategies for various cancers.
Objective: To evaluate the morphologic landscape of pancreatic ductal adenocarcinoma (PDAC), intratumor spatial heterogeneity, and the resulting clinical impact following post-neoadjuvant pancreatectomy.
Summary Background Data: The clinical value of PDAC morphologic subtypes and intratumor spatial heterogeneity post-treatment remains an open issue.
Materials And Methods: The study cohort included patients who underwent post-neoadjuvant pancreatectomy for PDAC at the University of Verona Hospital Trust between 2013 and 2019.
Article Synopsis
- The small intestine and ampulla can develop various benign tumors and tumor-like diseases that may resemble cancer, highlighting the need for pathologists to have a comprehensive understanding of these conditions.
- Key examples of these benign issues include Brunner gland lesions, different types of polyps, and various mesenchymal proliferations like inflammatory fibroid polyps and leiomyomas.
- The review aims to clarify the histopathological features of these benign conditions to aid pathologists in making accurate diagnoses and differentiating them from malignant tumors.