Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice.

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease with substantial mitochondrial and metabolic dysfunctions. SBMA is caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Activating or increasing the NAD-dependent deacetylase, SIRT3, reduced oxidative stress and death of cells modeling SBMA.

[Ultrasonographic study of detrusor thickness in patients with obstruction].

The diagnostic work up of patients with symptomatic benign prostatic hyperplasia is not always useful for diagnosing bladder outlet obstruction, especially if they are compared with pressure-flow studies. The authors make a review of the literature and a clinical study to demonstrate that alternative less invasive methods (ultrasound estimated bladder weight) can often replace pressure/flow studies.

[Management of sexual disorders in the diabetic patient. Considerations on diagnosis and therapy based on current pathogenetic and physiopathologic knowledge].

The sexual disorders in the diabetic males are quite frequent, particularly the erectil failures, which involve about 50% of these subjects. After a brief epidemiological note, the Authors review the recent advances about the pathogenesis of such a disturbance in the International Literature: values and limitations of up-to-date diagnostic examinations as well as therapeutic options are critically considered. From the diagnostic point of view the progress of the techniques involved both in the study of penile microcirculation and in the neurophysiopathology of the pelvic autonomic nervous system must be emphasized.

[Vesico-urethral and entero-urethral anastomosis: anatomo-surgical considerations and technical note].

Following radical prostatectomy or radical cystectomy with orthotopic ileal bladder (in male patients), the cervico-urethral or entero-urethral anastomosis are at high risk for urinary stress incontinence, due to the shortening of the urethral functional length as well as "unavoidable downward fall" of the perineum after sectioning of the anterior portion of the sacro-pubic ligaments. That descensus of the perineum, if uncorrected, might cause a functional extraabdominal positioning of the residual functional urethra; this feature is close similar to one of the most important pathogenetic factors of genuine stress incontinence in the female. In order to correct that perineal fall is advisable to perform the so-called "secondary sphincter" (after Rocca Rossetti, 1982) by suturing with the same stitches not only the anastomotic edges but the medial part of the levator ani (i.

[Radical prostatectomy: role of ultrasonography in the follow-up].

After a brief summary about surgical technique of radical prostatectomy and its indications in the different stages of prostatic cancer, the Authors describe complications and surgical sequelae of this operation. The Authors report a brief series. It is composed with 13 patients.