Publications by authors named "C Lozza"
Background: The use of mesenchymal stem cells (MSCs) appears to be a promising therapeutic approach for cardiac repair after myocardial infarction. However, clinical trials have revealed the need to improve their therapeutic efficacy. Recent evidence demonstrated that mitochondria undergo spontaneous transfer from damaged cells to MSCs, resulting in the activation of the cytoprotective and pro-angiogenic functions of recipient MSCs.
View Article and Find Full Text PDFPurpose: To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI).
Materials & Methods: Ischemia/Reperfusion was induced in C57BL/6J male mice. Left coronary artery was ligated during 45 min followed by reperfusion.
Article Synopsis
- The study aims to understand the impact of targeted and nontargeted effects of new cancer therapies using radioimmunotherapy (RIT) that utilizes alpha particle emitters and Auger emitters, highlighting their potential influence on treatment outcomes and side effects.
- Researchers found that a significant portion of cancer cell death was due to directed radiation effects, but a notable percentage was also attributed to nontargeted effects in surrounding cells, driven in part by biochemical processes involving lipid rafts and reactive oxygen species.
- The findings suggest that altering the cellular environment with specific drugs like statins could enhance survival rates and decrease damage during RIT, indicating that nontargeted effects are crucial considerations for improving cancer treatment efficacy.
Article Synopsis
- Researchers created a mouse monoclonal antibody, 16F12, that targets a receptor in ovarian tumors and tested its potential for both therapeutic and diagnostic applications in treating small-volume ovarian peritoneal carcinomatosis.
- They radiolabeled the antibody with different particles for therapy and imaging and applied two methods of administration: conventional intraperitoneal radioimmunotherapy (IP-RIT) and a brief intraperitoneal method (BIP-RIT).
- The study found that Bi-16F12 was more effective in BIP-RIT for tumor targeting, while Lu-16F12 performed better in delaying tumor growth in IP-RIT, indicating potential for 16F12 as a new treatment tool for ovarian