Publications by authors named "C Lopez-Menendez"
Purpose: Spastic paraplegia, intellectual disability, nystagmus, and obesity syndrome (SINO) is a rare autosomal dominant condition caused by heterozygous variants in KIDINS220. A total of 12 individuals are reported, comprising 8 with SINO and 4 with an autosomal recessive condition attributed to biallelic KIDINS220 variants.
Methods: In our international cohort, we have included 14 individuals, carrying 13 novel pathogenic KIDINS220 variants in heterozygous form.
In the adult mammalian brain, neural stem cells (NSCs) located in highly restricted niches sustain the generation of new neurons that integrate into existing circuits. A reduction in adult neurogenesis is linked to ageing and neurodegeneration, whereas dysregulation of proliferation and survival of NSCs have been hypothesized to be at the origin of glioma. Thus, unravelling the molecular underpinnings of the regulated activation that NSCs must undergo to proliferate and generate new progeny is of considerable relevance.
View Article and Find Full Text PDFObjective: The aim of this study was to assess the prognostic performance of postoperative 18F-fluorocholine PET/CT in patients with high-grade glioma (HGG).
Methods: Patients with HGG who underwent preoperative and postoperative 18F-fluorocholine PET/CT were prospectively enrolled in the study. Postoperative MRI was classified as complete versus incomplete resection.
Article Synopsis
- Cancer stem cells (CSC) play a critical role in tumor initiation, resistance to therapy, and metastasis, making understanding their mechanisms vital for new cancer treatments.
- Research using a specialized mouse model shows that E2A transcription factors are essential for maintaining cancer stemness and enabling metastasis in breast cancer, as their deletion severely reduced tumor-initiating ability and metastatic potential.
- E2A influences cancer behavior by regulating Snai1 transcription and is associated with poor outcomes in aggressive breast cancers, suggesting that targeting E2A could be a promising strategy in breast cancer therapy.