Publications by authors named "C Lopez de Silanes"

Article Synopsis
  • Deficiencies in the enzyme Mannosidase β (MANBA) are linked to neurological issues and infections, with a specific genetic polymorphism (rs7665090) associated with an increased risk of multiple sclerosis (MS).
  • A study analyzed lymphocytes from 152 MS patients and 112 healthy controls, revealing that MS patients displayed significantly lower MANBA mRNA expression and enzymatic activity compared to controls.
  • The rs7665090*GG genotype led to notable defects in β-mannosidase activity and lysosomal function, alongside reduced lymphocyte metabolic response in MS patients, indicating a clear connection between this genetic variant and MS immunopathology.
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Systemic inflammatory diseases could produce neurologic complications, and they are frequently incorporated in the differential diagnosis of neurological symptoms. There are wellestablished criteria to meet the diagnosis of neurologic manifestations of these systemic diseases. Methods: However, the range of clinical presentations varies in each condition, and the prevalence of these complications differs between studies.

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Background: The brain of migraineurs is hyperexcitable, particularly the occipital cortex, which is probably hypersensitive to light. Photophobia or hypersensitivity to light may be accounted for by an increased excitability of trigeminal, the visual pathways, and the occipital cortex.

Objective: To study light sensitivity and photophobia by assessing the response to light stimuli with functional magnetic resonance imaging-blood oxygenation level dependent (fMRI-BOLD) of the occipital cortex in migraineurs and in controls.

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Two patients suffering from ophthalmoplegic migraine had a strictly unilateral headache absolutely responsive to indomethacin, but not to other non-steroidal anti-inflammatory drugs, analgesics or corticosteroids. Such observations raise a therapeutic alternative and suggest that ophthalmoplegic migraine may present with different headache phenotypes.

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