Publications by authors named "C Lopez Menendez"
Purpose/background: Clozapine is the recommended drug for treatment-resistant schizophrenia. Drug response could be affected by numerous factors such as age, sex, body mass index, co-medication, consumption of xanthine-containing beverages, smoking, and genetic variants of the enzymes involved in clozapine metabolism (CYP1A2, CYP3A4, and, to a lesser extent, CYP2C19 and CYP2D6). This study evaluated genetic and nongenetic variables that may affect clozapine plasma concentrations in Uruguayan patients with schizophrenia.
View Article and Find Full Text PDFRaquel González and colleagues discuss the drugs available to HIV-exposed children to prevent malaria infection and the urgent need to evaluate alternative agents.
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- Maternal HIV and malaria infections during pregnancy can negatively impact the transfer of pertussis immunity from mothers to their infants.
- A study in Mozambique, involving 270 mother-infant pairs, found that mothers with HIV had significantly lower placental transfer of pertussis-specific antibodies compared to those without HIV.
- The findings suggest that addressing maternal HIV through healthcare interventions and immunization could help protect infants from pertussis.
Article Synopsis
- Perinatal mortality is notably high in low- and middle-income countries, with accurate fetal gestational age assessment essential for differentiating between prematurity and intrauterine growth restriction for better management strategies.
- The study conducted in Barcelona sought to validate post-mortem ultrasound measurements of the cerebellum as a method for estimating gestational age in cases of fetal and perinatal deaths.
- Findings demonstrated a strong correlation between various cerebellar measurements and gestational age, with the extrauterine transcerebellar diameter emerging as the most reliable predictor, regardless of the trimester in which the measurement was taken.
, a new structural indicator for water specially designed to be suitable for hydration and nanoconfined contexts, has been recently introduced and preliminarily applied for water in contact with self-assembled monolayers and graphene-like systems. This index enabled an accurate detection of defective high local density water molecules (called HDA-like given their structural resemblance with the high-density amorphous ice, HDA). In the present work, we shall apply this new metric to characterize protein hydration water with particular interest in protein binding sites.
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