Publications by authors named "C Lome-Maldonado"
Article Synopsis
- Aggressive large B-cell lymphomas (LBCL) have diverse biological traits; detecting MYC rearrangements (MYCr) is crucial for understanding their prognosis.
- Current recommendations urge performing cytogenetic tests on all aggressive LBCL cases to identify MYCr, but due to its low occurrence, affordable screening options are necessary.
- Researchers developed a scoring system and algorithm based on immunohistochemical profiles of CD10, LMO2, and MYC to effectively screen for MYCr, achieving high sensitivity and predictive values in both training and validation series.
Background: is a relevant gene involved in B-cell ontogeny and a survival predictor of aggressive large B-cell lymphomas (aLBCL). Most studies assessing mRNA expression have relied on microarray platforms or qRT-PCR methods, overlooking tissue morphology. In this study, we evaluate RNA expression by chromogenic in situ hybridization (CISH) in normal tissue and in a series of 82 aLBCL.
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- The study focuses on IDD-associated lymphoid proliferations linked to HIV, aiming to identify their clinical characteristics and outcomes in patients without organ transplants and on antiretroviral therapy.
- It analyzed data from 27 HIV+ male patients in Mexico, noting common conditions such as hyperplasia and a significant occurrence of Kaposi sarcoma among them.
- Results revealed a high prevalence of immunosuppression, with many patients showing severe immune deficiencies and some diagnosed with additional lymphomas, highlighting the need for better understanding and management of these conditions.*
Aggressive large B-cell lymphomas (aLBCL) include a heterogeneous group of lymphomas with diverse biological features. One of the approaches to the diagnosis of aLBCL is based on the identification of MYC rearrangements (MYC-R), in addition to BCL2 and BCL6 rearrangements by genetic techniques, mainly fluorescent in situ hybridization (FISH). Because of the low incidence of MYC-R, the identification of useful immunohistochemistry markers to select cases for MYC FISH testing may be useful in daily practice.
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- Extra-nodal NK/T-cell lymphoma, nasal type (ENKTCL) is a highly aggressive cancer linked to the Epstein-Barr virus, mainly affecting nasal areas.
- A comprehensive study of 209 ENKTCL cases identified key factors affecting survival, such as disease stage and genetic abnormalities, revealing distinct genetic clusters with different clinical outcomes.
- The research also highlighted a functional link between specific genetic mutations that promote cell growth, offering insights for potential treatment strategies for this aggressive lymphoma.