A deep reservoir for hydrogen drives intense degassing in the Bulqizë ophiolite.

Deep crustal production of hydrogen (H) is a potential source of primary energy if recoverable accumulations in geological formations are sufficiently large. We report direct measurements of an elevated outgassing rate of 84% (by volume) of H from the deep underground Bulqizë chromite mine in Albania. A minimum of 200 tons of H is vented annually from the mine's galleries, making it one of the largest recorded H flow rates to date.

Nocturnal plasma melatonin levels in migraine: a preliminary report.

We determined by radioimmunoassay plasma melatonin levels on blood samples drawn at 11 p.m. in migraine patients and control subjects.

Effects on migraine headache of MDL 72,222, an antagonist at neuronal 5-HT receptors. Double-blind, placebo-controlled study.

MDL 72,222 (1 alpha H, 5 alpha H-tropan-3 alpha-yl 3,5-dichlorobenzoate), a novel agent with antagonist activity at neuronal 5-HT receptors, was tested as an acute treatment for migraine pain under double-blind, placebo-controlled conditions. Forty-seven patients with common (n = 29) or classical (n = 8) migraine or mixed type with or without a psychogenic component (n = 10) received 20-40 mg MDL 72,222 (n = 24) or placebo (n = 23) intravenously during the headache phase of a migraine attack. MDL 72,222 was consistently superior to placebo in rapidly alleviating the migraine pain.