Engineered antigen-specific T regulatory cells suppress autoreactivity to the anti-glomerular basement membrane disease antigen.

Anti-glomerular basement membrane (anti-GBM) disease is accompanied by insufficient antigen-specific T regulatory cells (Tregs) and clonally expanded antigen-specific T conventional cells (Tconvs). In particular, this applied to the immunodominant T cell auto- epitope of type IV collagen, α3(IV)NC1135-145 , presented by HLA-DR15. Here, we investigated whether Tregs engineered to express GBM-T cell receptors (TCR) specific for α3(IV)NC1135- 145 better suppress autoimmunity.

Real-world efficacy and safety of universal 8-week glecaprevir/pibrentasvir in patients with chronic hepatitis C with early chronic kidney disease or pre-end-stage renal disease: Insights from a nationwide hepatisis C virus registry in Taiwan.

An 8-week regimen of glecaprevir/pibrentasvir is recommended for treatment-naïve patients with chronic hepatitis C (CHC). In alignment with the Taiwanese government's objective to eliminate hepatitis C by 2025, this study aimed to provide real-world evidence on the use of this regimen in treatment-naïve patients with chronic kidney disease (CKD) by using data from the Taiwan Association for the Study of the Liver HCV Registry (TACR). CKD was defined by an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.

Impact of PM, relative humidity, and temperature on sleep quality: a cross-sectional study in Taipei.

Introduction: TWe investigated impacts of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM), relative humidity (RH), and temperature on sleep stages and arousal.

Materials And Methods: A cross-sectional analysis involving 8,611 participants was conducted at a sleep center in Taipei.

Mitotic block and epigenetic repression underlie neurodevelopmental defects and neurobehavioral deficits in congenital heart disease.

Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease associated with microcephaly and poor neurodevelopmental outcomes. Here we show that the Ohia HLHS mouse model, with mutations in Sap130, a chromatin modifier, and Pcdha9, a cell adhesion protein, also exhibits microcephaly associated with mitotic block and increased apoptosis leading to impaired cortical neurogenesis. Transcriptome profiling, DNA methylation, and Sap130 ChIPseq analyses all demonstrate dysregulation of genes associated with autism and cognitive impairment.

The impact of age on comparative diagnostic accuracy of temporal artery thermometers and non-contact infrared thermometers for fever detection: a systematic review and meta-analysis.

Background: Non-invasive temporal artery thermometers (TATs) and non-contact infrared thermometers (NCITs) are increasingly used in community settings to measure body temperature. Existing research predominantly focuses on pediatric populations, yet the accuracy and precision of TATs and NCITs for fever screening across age groups remain unclear. This study aims to assess age-related differences in the diagnostic accuracy of TATs and NCITs for fever detection.