Publications by authors named "C Llano"
Article Synopsis
- Dilated cardiomyopathy is a complex heart condition linked to heart failure and arrhythmias, with about 50% of cases being inherited, highlighting the importance of genetic analysis.
- In a study of 65 patients, researchers re-evaluated 125 previously ambiguous genetic variants, reclassifying 12% as likely benign or pathogenic, suggesting improved understanding through better population frequency data.
- Their new algorithm indicated that 60.9% of remaining ambiguous variants had potential but unconfirmed harmful effects, while 24.5% might be benign, demonstrating the benefit of regularly updating genetic data for clearer interpretations.
In recent decades, the number of patients requiring biocompatible and resistant implants that differ from conventional alternatives dramatically increased. Among the most promising are the nanocomposites of biopolymers and nanomaterials, which pretend to combine the biocompatibility of biopolymers with the resistance of nanomaterials. However, few studies have focused on the in vivo study of the biocompatibility of these materials.
View Article and Find Full Text PDFGenetic interpretation of rare variants associated with arrhythmogenic cardiomyopathy (ACM) is essential due to their diagnostic implications. New data may relabel previous variant classifications, but how often reanalysis is necessary remains undefined. Five years ago, 39 rare ACM-related variants were identified in patients with features of cardiomyopathy.
View Article and Find Full Text PDFWe present isotopic and morphometric evidence suggesting the migration of farmers in the southern Andes in the period AD 1270-1420, leading up to the Inka conquest occurring ~ AD 1400. This is based on the interdisciplinary study of human remains from archaeological cemeteries in the Andean Uspallata Valley (Argentina), located in the southern frontier of the Inka Empire. The studied samples span AD 800-1500, encompassing the highly dynamic Late Intermediate Period and culminating with the imperial expansion.
View Article and Find Full Text PDFObjectives: The goal of this article is to assess the scale of human paleomobility and ecological complementarity between the lowlands and highlands in the southern Andes during the last 2,300 years. By providing isotope results for human bone and teeth samples, we assess a hypothesis of "high residential mobility" suggested on the basis of oxygen isotopes from human remains.
Methods: We develop an isotopic assessment of human mobility in a mountain landscape combining strontium and oxygen isotopes.