Cell-specific oxidative metabolism of the renal cortex.

Unlabelled: The metabolic health of the kidney is a primary determinant of the risk of progressive kidney disease. Our understanding of the metabolic processes that fuel kidney functions is limited by the kidney's structural and functional heterogeneity. As the kidney contains many different cell types, we hypothesize that intra-renal mitochondrial heterogeneity contributes to cell-specific metabolism.

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis.

Mitochondrial DNA (mtDNA) mutations are frequent in cancer, yet their precise role in cancer progression remains debated. To functionally evaluate the impact of mtDNA variants on tumor growth and metastasis, we developed an enhanced cytoplasmic hybrid (cybrid) generation protocol and established isogenic human melanoma cybrid lines with wild-type mtDNA or pathogenic mtDNA mutations with partial or complete loss of mitochondrial oxidative function. Cybrids with homoplasmic levels of pathogenic mtDNA reliably established tumors despite dysfunctional oxidative phosphorylation.

Deep Learning System for User Identification Using Sensors on Doorknobs.

Door access control systems are important to protect the security and integrity of physical spaces. Accuracy and speed are important factors that govern their performance. In this paper, we investigate a novel approach to identify users by measuring patterns of their interactions with a doorknob via an embedded accelerometer and gyroscope and by applying deep-learning-based algorithms to these measurements.