AI-Assisted Post Contrast Brain MRI: Eighty Percent Reduction in Contrast Dose.

Objectives: In the context of growing safety concerns regarding the use of gadolinium-based contrast agents in contrast-enhanced MRI, there is a need for dose reduction without compromising diagnostic accuracy. A deep learning (DL) method is proposed and evaluated in this study for predicting full-dose contrast-enhanced T1w images from multiparametric MRI acquired with 20% of the standard dose of gadolinium-based contrast agents.

Materials And Methods: This multicentric prospective study leveraged multiparametric brain MRIs acquired between March and July 2024.

Chain-End Controlled Depolymerization Selectivity in α,α-Disubstituted Propionate PHAs with Dual Closed-Loop Recycling and Record-High Melting Temperature.

Within the large poly(3-hydroxyalkanoate) (PHA) family, C3 propionates are much less studied than C4 butyrates, with the exception of α,α-disubstituted propionate PHAs, particularly poly(3-hydroxy-2,2-dimethylpropionate), P3H(Me)P, due to its high melting temperature ( ∼ 230 °C) and crystallinity (∼76%). However, inefficient synthetic routes to its monomer 2,2-dimethylpropiolactone [(Me)PL] and extreme brittleness of P3H(Me)P largely hinder its broad applications. Here, we introduce simple, efficient step-growth polycondensation (SGP) of a hydroxyacid or methyl ester to afford P3H(Me)P with low to medium molar mass, which is then utilized to produce lactones through base-catalyzed depolymerization.

Revisiting the activity of two poly(vinyl chloride)- and polyethylene-degrading enzymes.

Biocatalytic degradation of non-hydrolyzable plastics is a rapidly growing field of research, driven by the global accumulation of waste. Enzymes capable of cleaving the carbon-carbon bonds in synthetic polymers are highly sought-after as they may provide tools for environmentally friendly plastic recycling. Despite some reports of oxidative enzymes acting on non-hydrolyzable plastics, including polyethylene or poly(vinyl chloride), the notion that these materials are susceptible to efficient enzymatic degradation remains controversial, partly driven by a general lack of studies independently reproducing previous observations.

Socio-ecological impacts of extreme weather events in two informal settlements in Nairobi, Kenya.

Climate change is expected to profoundly impact health and coping and widen social and environmental inequalities. People living in informal settlements are especially vulnerable to climate change as they are often located in ecologically sensitive areas more susceptible to extreme weather events (EWEs), such as floods, droughts, and heat waves. Women residing in informal settlements are especially vulnerable to climate change and related EWEs because they are more likely to experience worse health-related impacts than men but are less likely to have access to health-related services.

Supporting equitable care of patients transferred from police watch-houses to the emergency department: A qualitative study of the perspectives of emergency doctors.

Objective: People detained in short-term police custody often have complex health conditions that may necessitate emergency care, yet little is known about their management in EDs. The present study aimed to understand ED doctors' experiences and perceptions regarding the appropriateness and management of detainee transfers from police watch-houses to the EDs.

Methods: A qualitative descriptive study, using semi-structured interviews undertaken with ED doctors working in five purposively sampled EDs across Queensland, Australia.