Four-year study of cobalt and chromium blood levels in patients managed with two different metal-on-metal total hip replacements.

Background: Metal-on-metal total hip prostheses will produce a certain amount of wear debris. This results in increased whole-blood metal levels, which may cause adverse effects. It is not known to what extent the problem has been overcome by advances in alloy technology.

Retrieval study of uncemented metal-metal hip prostheses revised for early loosening.

A tribologic assessment was performed on 22 metal-metal hip prostheses from a single manufacturer, following removal for early aseptic loosening after a mean service life of 32 months (range, 12-59 months). The mean linear wear rate was 7.6 microm/year (range, 2.

Are allergic reactions to skin clips associated with delayed wound healing?

Background: Metal skin clips are used in surgery. They may contain metals that might cause allergic reactions and delayed wound healing.

Methods: The metal composition of 18 different surgical clamps was examined.

Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells.

Increased ribonucleotide reductase (RR) activity has been linked with malignant transformation and tumor cell growth. Therefore, this enzyme is considered to be an excellent target for cancer chemotherapy. We have examined the effects of a newly patented RR inhibitor, trimidox (3,4,5-trihydroxybenzohydroxamidoxime).

[Synergistic cytotoxic effects of chemotherapy in colon tumor cells by simultaneous inhibition of de novo and salvage energy metabolism pathways].

The success of chemotherapy of colon tumours is currently limited. We have therefore used the human colon tumour cell line HT-29 to evaluate the cytotoxic effects of various drug combinations. Trimidox (3,4,5-trihydroxybenzamidoxime), a recently patented inhibitor of ribonucleotide reductase was combined with cytosinearabinoside (Ara-C) or 2',2'-difluorodeoxycytidine (DFDC) in order to inhibit both pyrimidine de novo and salvage pathways.